Literature DB >> 6705148

Mutagenicity of betel quid and its ingredients using mammalian test systems.

L P Shirname, M M Menon, S V Bhide.   

Abstract

The mutagenic potential of betel quid and its ingredients (known colloquially as PAN) were tested in two short term mutagenicity assays, the micronucleus test and a mammalian gene mutation test. Betel quid with tobacco, tobacco, betel nut and one of its alkaloids arecoline were positive in both tests. Extracts of betel quid and arecaidine (a metabolite of arecoline present in Betel nut) were negative. The data presented correlate well with our previous tumorigenicity data on these compounds.

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Year:  1984        PMID： 6705148     DOI： 10.1093/carcin/5.4.501

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  9 in total

1.  In vitro genotoxic effects of areca nut extract and arecoline.

Authors:  B J Dave; A H Trivedi; S G Adhvaryu
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population.

Authors:  Virendra Singh; Laishram C Singh; Avninder P Singh; Jagannath Sharma; Bibhuti B Borthakur; Arundhati Debnath; Avdhesh K Rai; Rup K Phukan; Jagadish Mahanta; Amal C Kataki; Sujala Kapur; Sunita Saxena
Journal:  Am J Cancer Res       Date:  2015-02-15       Impact factor: 6.166

3.  Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation.

Authors:  Hsiao-Ling Cheng; Shu-Jem Su; Li-Wen Huang; Bau-Shan Hsieh; Yu-Chen Hu; Thu-Ching Hung; Kee-Lung Chang
Journal:  Mol Cancer       Date:  2010-05-28       Impact factor: 27.401

Review 4.  Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review.

Authors:  Nuno G Oliveira; Daniela L Ramos; Ricardo Jorge Dinis-Oliveira
Journal:  Arch Toxicol       Date:  2020-10-24       Impact factor: 5.153

5.  The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer.

Authors:  Ping-Ho Chen; Bin Huang; Tien-Yu Shieh; Yan-Hsiung Wang; Yuk-Kwan Chen; Ju-Hui Wu; Jhen-Hao Huang; Chun-Chia Chen; Ka-Wo Lee
Journal:  ScientificWorldJournal       Date:  2014-10-15

6.  Expression of a splice variant of CYP26B1 in betel quid-related oral cancer.

Authors:  Ping-Ho Chen; Ka-Wo Lee; Cheng-Chieh Hsu; Jeff Yi-Fu Chen; Yan-Hsiung Wang; Ker-Kong Chen; Hui-Min David Wang; Hurng-Wern Huang; Bin Huang
Journal:  ScientificWorldJournal       Date:  2014-07-07

7.  Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Authors:  Yu-Chu Wang; Jau-Ling Huang; Ka-Wo Lee; Hsing-Han Lu; Yuan-Jen Lin; Long-Fong Chen; Chung-Sheng Wang; Yun-Chiao Cheng; Zih-Ting Zeng; Pei-Yi Chu; Chang-Shen Lin
Journal:  Cancers (Basel)       Date:  2020-07-25       Impact factor: 6.639

Review 8.  Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.

Authors:  Che-Yi Lin; Tien-Szu Pan; Chun-Chan Ting; Shih-Shin Liang; Shu-Hung Huang; Hsiu-Yueh Liu; Edward Cheng-Chuan Ko; Chung-Wei Wu; Jen-Yang Tang; Ping-Ho Chen
Journal:  ScientificWorldJournal       Date:  2013-08-01

9.  The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study.

Authors:  Madhavi Priyanka Paranagama; Nadisha Sewwandi Piyarathne; Tharanga Lakmali Nandasena; Sumedha Jayatilake; Ayanthi Navaratne; Bandula Prasanna Galhena; Senani Williams; Jayantha Rajapakse; Kiyoshi Kita
Journal:  BMC Complement Med Ther       Date:  2020-08-20
  9 in total

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