Literature DB >> 6704718

Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in rats.

G L Wenk, D S Olton.   

Abstract

The present experiment was designed to investigate the depletion and possible recovery of neocortical choline acetyltransferase (ChAT) levels following damage to the basal forebrain cholinergic (Ch) system in rats. A unilateral injection of ibotenic acid was made into the left nucleus basalis of Meynert (nbM). Seven days after the injection, neocortical ChAT levels had decreased 60%. After 3 months it had returned to normal. Thus this system shows extensive plasticity and recovery of function with time.

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Year:  1984        PMID： 6704718     DOI： 10.1016/0006-8993(84)91468-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  High-affinity transport of choline and amino acid neurotransmitters in synaptosomes from brain regions after lesioning the nucleus basalis magnocellularis of young and aged rats.

Authors:  J Gomeza; C Aragón; C Giménez
Journal:  Neurochem Res       Date:  1992-04       Impact factor: 3.996

2.  Effects of lesion of the cholinergic basal forebrain nuclei on the activity of glutamatergic and GABAergic systems in the rat frontal cortex and hippocampus.

Authors:  G Reine; D Samuel; A Nieoullon; L Kerkerian-Le Goff
Journal:  J Neural Transm Gen Sect       Date:  1992

3.  Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex.

Authors:  G Weskamp; H P Lorez; H H Keller; U Otten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-12       Impact factor: 3.000

4.  Intracortical grafts of embryonic basal forebrain tissue restore low voltage fast activity in rats with basal forebrain lesions.

Authors:  C H Vanderwolf; A Fine; R K Cooley
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

5.  Nucleus basalis magnocellularis: optimal coordinates for selective reduction of choline acetyltransferase in frontal neocortex by ibotenic acid injections.

Authors:  G L Wenk; B Cribbs; L McCall
Journal:  Exp Brain Res       Date:  1984       Impact factor: 1.972

6.  Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

Authors:  A Fine; S B Dunnett; A Björklund; S D Iversen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

7.  Effects of ibotenic acid lesions of the basal forebrain on serial reversal learning in marmosets.

Authors:  R M Ridley; H F Baker; B Drewett; J A Johnson
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

8.  Substitution of natural sensory input by artificial neurostimulation of an amputated trigeminal nerve does not prevent the degeneration of basal forebrain cholinergic circuits projecting to the somatosensory cortex.

Authors:  Celia Herrera-Rincon; Fivos Panetsos
Journal:  Front Cell Neurosci       Date:  2014-11-14       Impact factor: 5.505
  8 in total

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