Literature DB >> 6704104

Age-related changes in unscheduled DNA synthesis by rat hepatocytes.

M M Plesko, A Richardson.   

Abstract

Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.

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Year:  1984        PMID： 6704104     DOI： 10.1016/0006-291x(84)91455-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

1.  Influence of age, sex and strain on the in vitro induction of unscheduled DNA synthesis in rat hepatocyte primary cultures.

Authors:  G S Probst; L E Hill
Journal:  Cell Biol Toxicol       Date:  1987-06       Impact factor: 6.691

2.  High sensitivity of LEC rats with chronic hepatitis to hepatocarcinogenesis: decreases in unscheduled and replicative DNA synthesis of the hepatocytes.

Authors:  H Sakamoto; N Sawada; Y Kamimura; K Enomoto; M Mori
Journal:  Jpn J Cancer Res       Date:  1993-09
  2 in total

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