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Literature DB >> 6703958

Topical treatment of experimental herpes simplex keratouveitis with 2'-O-glycylacyclovir. A water-soluble ester of acyclovir.

P C Maudgal, K De Clercq, J Descamps, L Missotten.

Abstract

2'-O-glycylacyclovir, a water-soluble ester derivative of acyclovir, has proved efficacious in the topical treatment of epithelial and stromal herpes simplex keratitis, and iritis therewith associated, when administered as a 1% eyedrop formulation to rabbits.

Entities: Chemical Disease Species

Mesh：

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Year: 1984 PMID： 6703958 DOI： 10.1001/archopht.1984.01040030118049

Source DB: PubMed Journal: Arch Ophthalmol ISSN： 0003-9950

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Cited

13 in total

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Review 3. Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy.

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4. Extended release of ketotifen from silica shell nanoparticle-laden hydrogel contact lenses: in vitro and in vivo evaluation.

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Journal: J Mater Sci Mater Med Date: 2016-05-13 Impact factor: 3.896

10. Preliminary data suggest a role for bacterial superinfection of a viral keratitis after zosteriform spread of herpes simplex virus to the eye of the mouse.

Authors: C Claoué
Journal: J R Soc Med Date: 1988-08 Impact factor: 18.000

Topical treatment of experimental herpes simplex keratouveitis with 2'-O-glycylacyclovir. A water-soluble ester of acyclovir.

Review 1. Ocular drug delivery. Pharmacokinetic considerations.

Review 2. Amino Acids in the Development of Prodrugs.

Review 3. Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy.

4. Extended release of ketotifen from silica shell nanoparticle-laden hydrogel contact lenses: in vitro and in vivo evaluation.

5. Water-soluble, solution-stable, and biolabile N-substituted (aminomethyl)benzoate ester prodrugs of acyclovir.

Review 6. Rational acyclovir therapy in herpetic eye disease.

7. Preparation and ocular pharmacokinetics of ganciclovir liposomes.

8. Topical BVDU plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis. A pilot study.

9. Novel drug delivery approaches on antiviral and antiretroviral agents.

10. Preliminary data suggest a role for bacterial superinfection of a viral keratitis after zosteriform spread of herpes simplex virus to the eye of the mouse.