Literature DB >> 6701910

Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary.

S Govoni, L Lucchi, F Battaini, P F Spano, M Trabucchi.   

Abstract

The effect of lead exposure on dopaminergic mechanisms regulating prolactin (PRL) secretion was studied in rats by measuring dopamine (DA) and dihydroxyphenylacetic acid hypothalamic concentrations and DA receptor density in the hypothalamus and pituitary of lead-exposed animals. [3H]Sulpiride was used as dopamine receptor ligand. A decrease of dihydroxyphenylacetic acid (DOPAC) hypothalamic concentrations and a decrease of DA receptor density in the pituitary are shown. The decreased [3H]sulpiride binding in the pituitary is consistent with the elevated serum PRL concentrations previously described in lead-exposed rats.

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Year:  1984        PMID： 6701910     DOI： 10.1016/0378-4274(84)90154-1

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  7 in total

Review 1.  Occupational and environmental agents as endocrine disruptors: experimental and human evidence.

Authors:  A Baccarelli; A C Pesatori; P A Bertazzi
Journal:  J Endocrinol Invest       Date:  2000-12       Impact factor: 4.256

2.  Correlation between lead and prolactin in males exposed and unexposed to lead in Buenos Aires (Argentina) area.

Authors:  O E Roses; S Alvarez; M I Conti; R A Nóbile; E C Villaamil
Journal:  Bull Environ Contam Toxicol       Date:  1989-03       Impact factor: 2.151

Review 3.  Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect.

Authors:  V M Andrade; M L Mateus; M C Batoréu; M Aschner; A P Marreilha dos Santos
Journal:  Biol Trace Elem Res       Date:  2015-02-20       Impact factor: 3.738

4.  Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development.

Authors:  M V Shailesh Kumar; T Desiraju
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

Review 5.  The effect of lead intoxication on endocrine functions.

Authors:  K K Doumouchtsis; S K Doumouchtsis; E K Doumouchtsis; D N Perrea
Journal:  J Endocrinol Invest       Date:  2009-02       Impact factor: 4.256

6.  Pituitary function following treatment with reproductive toxins.

Authors:  R L Cooper; J M Goldman; G L Rehnberg
Journal:  Environ Health Perspect       Date:  1986-12       Impact factor: 9.031

7.  Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice.

Authors:  J Leigh Leasure; Anand Giddabasappa; Shawntay Chaney; Jerry E Johnson; Konstantinos Pothakos; Yuen Sum Lau; Donald A Fox
Journal:  Environ Health Perspect       Date:  2008-03       Impact factor: 9.031
  7 in total

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