Literature DB >> 6701780

Hemoglobin solution--from tetramer to polymer.

G S Moss, S A Gould, L R Sehgal, H L Sehgal, A L Rosen.   

Abstract

Efforts to produce a clinically acceptable hemoglobin solution that could function as a temporary oxygen carrier have evolved through several stages. Beginning with the simple tetramer, we have lowered the affinity state by pyridoxylation and then polymerized the modified tetramer. This new substance, polyhemoglobin, has a normal oxygen capacity and a half-life of 38 hours. Issues of nephrotoxicity and immunocompetence after infusion remain to be defined.

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Year:  1984        PMID： 6701780

Source DB:  PubMed          Journal:  Surgery        ISSN： 0039-6060            Impact factor:   3.982


  4 in total

1.  New directions for the hospital blood transfusion service.

Authors:  G H Growe; M Sinclair
Journal:  CMAJ       Date:  1988-02-01       Impact factor: 8.262

Review 2.  Red cell substitutes: present status.

Authors:  L R Sehgal; H L Sehgal; S A Gould; A L Rosen; R DeWoskin; G S Moss
Journal:  Indian J Pediatr       Date:  1987 May-Jun       Impact factor: 1.967

3.  The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: scientific rationale, study design, and results.

Authors:  Ernest E Moore; Jeffrey L Johnson; Frederick A Moore; Hunter B Moore
Journal:  Crit Care Clin       Date:  2009-04       Impact factor: 3.598

4.  The efficacy of polymerized pyridoxylated hemoglobin solution as an O2 carrier.

Authors:  S A Gould; L R Sehgal; A L Rosen; H L Sehgal; G S Moss
Journal:  Ann Surg       Date:  1990-04       Impact factor: 12.969
  4 in total

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