Literature DB >> 6700931

Renal cell carcinoma--xenotransplantation into immuno-suppressed mice.

L Kopper, E Magyarosy, P Nagy, K Lapis, I Számel, S Eckhardt, S Csata, G Wabrosch, D Répássy.   

Abstract

21 human renal cell carcinomas (RCC) were xenotransplanted into artificially immunosuppressed mice. 4 tumors grew successfully retaining some characteristics of the primary tumors (according to morphology and karyotype analysis), but losing metastatic capacity. One of the serially transplantable tumors (HT 40) with hyperdiploid cellular DNA content and estrogen receptor positivity failed to respond to the single maximally tolerated dose of several cytotoxic agents.

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Year:  1984        PMID： 6700931     DOI： 10.1159/000225784

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  4 in total

Review 1.  Patient-derived tumour xenografts as models for oncology drug development.

Authors:  John J Tentler; Aik Choon Tan; Colin D Weekes; Antonio Jimeno; Stephen Leong; Todd M Pitts; John J Arcaroli; Wells A Messersmith; S Gail Eckhardt
Journal:  Nat Rev Clin Oncol       Date:  2012-04-17       Impact factor: 66.675

2.  A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma.

Authors:  Sharanya Sivanand; Samuel Peña-Llopis; Hong Zhao; Blanka Kucejova; Patrick Spence; Andrea Pavia-Jimenez; Toshinari Yamasaki; David J McBride; Jessica Gillen; Nicholas C Wolff; Lorraine Morlock; Yair Lotan; Ganesh V Raj; Arthur Sagalowsky; Vitaly Margulis; Jeffrey A Cadeddu; Mark T Ross; David R Bentley; Wareef Kabbani; Xian-Jin Xie; Payal Kapur; Noelle S Williams; James Brugarolas
Journal:  Sci Transl Med       Date:  2012-06-06       Impact factor: 17.956

3.  Establishment and characterization of a new transplantable pancreatic cancer xenograft (PZX-5) in immunosuppressed mice.

Authors:  A Zalatnai; J Bocsi; F Timár; I Babó
Journal:  Int J Pancreatol       Date:  1998-02

4.  Experience with hormone receptors in renal cancer.

Authors:  I Romics; C Rüssel; D Bach
Journal:  Int Urol Nephrol       Date:  1990       Impact factor: 2.370
  4 in total

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