Literature DB >> 6700638

Sterols of Leishmania species. Implications for biosynthesis.

L J Goad, G G Holz, D H Beach.   

Abstract

The major sterol of promastigotes of stocks of Leishmania tropica, L. donovani and 3 subspecies of L. mexicana has been identified as ergosta-5,7,24(28)-trien-3 beta-ol; and of an L. major stock as ergosta-7,24(28)-dien-3 beta-ol. 24-Methylcholesta-5,7,22-trien-3 beta-ol and 24-ethylcholesta-5,7,22-trien-3 beta-ol were minor constituents, and traces of ergosta-5,7,22,24(28)-tetraen-3 beta-ol and a C27-diene were also recognized in some species. Lanosterol and 4,4-dimethylcholesta-8,24-dien-3 beta-ol were detected in all species studied, and squalene was identified in a stock of L. tropica. The sterol composition of members of the genus Leishmania and the sterol biosynthetic pathways it implies are characteristic of yeast and other fungi.

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Year:  1984        PMID： 6700638     DOI： 10.1016/0166-6851(84)90004-5

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  38 in total

1.  Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

Authors:  A Montalvetti; J Peña-Díaz; R Hurtado; L M Ruiz-Pérez; D González-Pacanowska
Journal:  Biochem J       Date:  2000-07-01       Impact factor: 3.857

2.  Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani.

Authors:  Bidyut Purkait; Ashish Kumar; Nilay Nandi; Abul Hasan Sardar; Sushmita Das; Sudeep Kumar; Krishna Pandey; Vidyananda Ravidas; Manish Kumar; Tripti De; Dharmendra Singh; Pradeep Das
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191

3.  In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.

Authors:  Dhiraj Kumar; Arpita Kulshrestha; Ruchi Singh; Poonam Salotra
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

4.  Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana.

Authors:  M L Ginger; M L Chance; L J Goad
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

5.  Sterol and genomic analyses validate the sponge biomarker hypothesis.

Authors:  David A Gold; Jonathan Grabenstatter; Alex de Mendoza; Ana Riesgo; Iñaki Ruiz-Trillo; Roger E Summons
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-22       Impact factor: 11.205

6.  Fluidity-dependent Mg2(+)-ATPase activity in membranes from Leishmania donovani promastigotes.

Authors:  M Dutta; R Bandyopadhyay; C Ghosh; M K Basu
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

7.  A soluble 3-hydroxy-3-methylglutaryl-CoA reductase in the protozoan Trypanosoma cruzi.

Authors:  J Peña-Díaz; A Montalvetti; A Camacho; C Gallego; L M Ruiz-Perez; D Gonzalez-Pacanowska
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

8.  Sterol phylogenesis and algal evolution.

Authors:  W D Nes; R A Norton; F G Crumley; S J Madigan; E R Katz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

9.  Effects of an azasterol inhibitor of sterol 24-transmethylation on sterol biosynthesis and growth of Leishmania donovani promastigotes.

Authors:  P A Haughan; M L Chance; L J Goad
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

10.  Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

Authors:  Wanderley de Souza; Juliany Cola Fernandes Rodrigues
Journal:  Interdiscip Perspect Infect Dis       Date:  2009-08-05
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