Literature DB >> 6699835

Aluminum in the joint tissues of chronic renal failure patients treated with regular hemodialysis and aluminum compounds.

P Netter, M Kessler, D Burnel, M F Hutin, S Delones, J Benoit, A Gaucher.   

Abstract

We studied the concentrations of aluminum in the articular tissues of 5 hemodialysed patients treated with aluminum compounds. Aluminum crosses the synovial barrier, is found in synovial fluid (SF) and accumulates in the joint structures (synovial membrane and joint cartilage). The concentrations found in synovial tissue were 2.7 to 10 times control values, in SF 2.5 to 8 times the control concentrations and in cartilage 2.6 times the control concentrations. Transmission electron microscopy showed localization of aluminum in the lysosomal structures and wavelength dispersive microprobe analysis showed aluminum in cellular components associated with phosphate. The possible toxicity of aluminum to joints merits further investigations.

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Year:  1984        PMID： 6699835

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  6 in total

1.  Destructive spondyloarthropathy and radiographic follow-up in hemodialysis patients.

Authors:  C Orzincolo; P L Bedani; P N Scutellari; P Cardona; F Trotta; P Gilli
Journal:  Skeletal Radiol       Date:  1990       Impact factor: 2.199

Review 2.  Does aluminium have a pathogenic role in dialysis associated arthropathy?

Authors:  P Netter; M Kessler; A Gaucher; B Bannwarth
Journal:  Ann Rheum Dis       Date:  1990-08       Impact factor: 19.103

Review 3.  Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

Authors:  Daniel Krewski; Robert A Yokel; Evert Nieboer; David Borchelt; Joshua Cohen; Jean Harry; Sam Kacew; Joan Lindsay; Amal M Mahfouz; Virginie Rondeau
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2007       Impact factor: 6.393

Review 4.  Pathological fractures and lytic bone lesion of the femoral neck associated with beta 2-microglobulin amyloid deposition in long-term dialysis patients.

Authors:  G F Scheumann; M Holch; M L Nerlich; A Brandis; H Ostertag; H Tscherne
Journal:  Arch Orthop Trauma Surg       Date:  1991       Impact factor: 3.067

Review 5.  [Aluminum toxicity].

Authors:  H V Henning
Journal:  Klin Wochenschr       Date:  1989-12-15

6.  Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis.

Authors:  P D Gorevic; P C Munoz; T T Casey; C R DiRaimondo; W J Stone; F C Prelli; M M Rodrigues; M D Poulik; B Frangione
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205
  6 in total

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