[Prenatal diagnosis of IUGR by assessing the multiple hormone concentration in maternal peripheral blood].

The serum concentrations of multiple hormones in maternal peripheral vein during pregnancy were simultaneously measured to determine whether it is possible to discriminate IUGR from normal pregnancy. Blood samples were obtained when the patients were at 30 to 35 weeks of gestation and IUGR was confirmed after delivery. The mean concentrations of progesterone and estriol were significantly lower in maternal vein with IUGR than those in normal pregnancy. On the other hand, the mean concentrations of 16 alpha-hydroxypregnenolone and DHA were significantly higher in the patients with IUGR than those in the patients with normal fetus. However, it seemed impossible to discriminate IUGR from normal completely, since the steroid values in IUGR overlapped in normal range. An attempt was made to apply the data to the computation in multivariate analysis. The computer used for this analysis was an HITAC-M-180 and the package was BMD. Using the principal component analysis, normal and IUGR groups were roughly separated. However, no definite border line could be drawn between normal and IUGR. The discriminant analysis was then applied to separate two groups. Using the estriol value as a variable, 58% reliability was achieved in separate two groups. 93% reliability was achieved when the values of 6 steroids were used. And finally, when the clinical data represented by the length of the uterine fundus and the girth were added to the steroidal values, 100% possibility was obtained in separate two groups.