Literature DB >> 669897

Photosensitive cataractogens, chlorpromazine and methoxypsoralen, cause DNA repair synthesis in lens epithelial cells.

J G Jose, K L Yielding.   

Abstract

Autoradiographic techniques showed that photoactivation of methoxypsoralen opr chlorpomazine caused diffuse nuclear labeling of lens epithelial cells by thymidine. Chlorpromazine and light also induced thymidine incorporation into lymphocytes, whereas light or drug alone did not cause unscheduled DNA synthesis.

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Year:  1978        PMID： 669897

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  5 in total

Review 1.  Ocular adverse effects of neuropsychiatric agents. Incidence and management.

Authors:  T Oshika
Journal:  Drug Saf       Date:  1995-04       Impact factor: 5.606

2.  Histologic observations of the lenses of psoralen + UVA treated albino rats and a theory as to the underlying mechanism.

Authors:  J G Jose; H R Koch; A Respondek
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1982       Impact factor: 3.117

3.  Photomutagenesis by chlorinated phenothiazine tranquilizers.

Authors:  J G Jose
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

4.  8-methoxypsoralen and long ultraviolet effects on the rat lens: experiments with high dosage.

Authors:  H R Koch; R Beitzen; F Kremer; G Chioralia; H Baurmann; J Megaw; K Gardner; S Lerman
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1982       Impact factor: 3.117

5.  Welding arc maculopathy and fluphenazine.

Authors:  W J Power; S P Travers; D J Mooney
Journal:  Br J Ophthalmol       Date:  1991-07       Impact factor: 4.638
  5 in total

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