Literature DB >> 669885

Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine).

P Lefrancier, M Derrien, I Lederman, F Nief, J Choay, E Lederer.   

Abstract

In our continued efforts to elucidate the relationship between the structure and the immunoadjuvant, antiinfectious or mitogenic activity of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), we report the synthesis of 11 new analogs. Five of them present some modifications in the N-acetyl-muramyl moiety.

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Year:  1978        PMID： 669885     DOI： 10.1111/j.1399-3011.1978.tb02851.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  4 in total

1.  Induction of antibodies directed against self and altered-self determinants by a synthetic adjuvant, muramyl dipeptide and some of its derivatives.

Authors:  I Löwy; C Leclerc; L Chedid
Journal:  Immunology       Date:  1980-03       Impact factor: 7.397

2.  Colony-stimulating activity induced by synthetic muramyl peptides: variation with chemical structure and association with anti-infectious activity.

Authors:  A Galelli; P Lefrancier; L Chedid
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441

3.  Immunological castration of male mice by a totally synthetic vaccine administered in saline.

Authors:  C Carelli; F Audibert; J Gaillard; L Chedid
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

4.  Muramyl peptides. Variation of somnogenic activity with structure.

Authors:  J M Krueger; J Walter; M L Karnovsky; L Chedid; J P Choay; P Lefrancier; E Lederer
Journal:  J Exp Med       Date:  1984-01-01       Impact factor: 14.307
  4 in total

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