| Literature DB >> 6698758 |
A P Travassos da Rosa, R B Tesh, F P Pinheiro, J F Travassos da Rosa, P H Peralta, D L Knudson.
Abstract
The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable; but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.Entities:
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Year: 1984 PMID: 6698758 DOI: 10.1159/000149501
Source DB: PubMed Journal: Intervirology ISSN: 0300-5526 Impact factor: 1.763