Literature DB >> 6698665

Nitroimidazoles in the treatment of trichomoniasis, giardiasis, and amebiasis.

J F Rossignol, H Maisonneuve, Y W Cho.   

Abstract

Nitroimidazoles have been extensively evaluated in the treatment of trichomoniasis, giardiasis, liver and intestinal amebiasis. The most widely used are metronidazole, tinidazole, ornidazole, and secnidazole. Tinidazole, ornidazole, and secnidazole have a much longer half-life than metronidazole, allowing single-dose or once daily administration. Nitro-5-imidazoles remain extremely effective drugs for treating protozoans, Trichomonas vaginalis, Entamoeba histolytica, and Giardia intestinalis. Although all are suspected of potential carcinogenicity, they are the drugs of choice for treating protozoal infections.

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Year:  1984        PMID： 6698665

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN： 0174-4879


  13 in total

1.  Anti-Trichomonas vaginalis monoclonal antibodies inducing complement-dependent cytotoxicity.

Authors:  N Moav; E Draghi; A David; D Gold
Journal:  Immunology       Date:  1988-01       Impact factor: 7.397

Review 2.  Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.

Authors:  K C Lamp; C D Freeman; N E Klutman; M K Lacy
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

Review 3.  From Leningrad to the day-care center. The ubiquitous Giardia lamblia.

Authors:  W X Shandera
Journal:  West J Med       Date:  1990-08

4.  A systematic review of the literature on mechanisms of 5-nitroimidazole resistance in Trichomonas vaginalis.

Authors:  Keonte J Graves; Jan Novak; W Evan Secor; Patricia J Kissinger; Jane R Schwebke; Christina A Muzny
Journal:  Parasitology       Date:  2020-07-30       Impact factor: 3.234

Review 5.  Treatment of giardiasis.

Authors:  T B Gardner; D R Hill
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

Review 6.  Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis.

Authors:  J C Gillis; L R Wiseman
Journal:  Drugs       Date:  1996-04       Impact factor: 9.546

7.  The tropical brown alga Lobophora variegata: a source of antiprotozoal compounds.

Authors:  Zulema Cantillo-Ciau; Rosa Moo-Puc; Leovigildo Quijano; Yolanda Freile-Pelegrín
Journal:  Mar Drugs       Date:  2010-04-16       Impact factor: 5.118

8.  Single-dose ornidazole versus seven-day metronidazole therapy of giardiasis in Kibbutzim children in Israel.

Authors:  B Oren; E Schgurensky; M Ephros; I Tamir; R Raz
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-11       Impact factor: 3.267

9.  Chemoprophylactic activity of nitazoxanide in experimental model of mammary gland carcinoma in rats.

Authors:  Ajay Kumar Pal; Mukesh Nandave; Gaurav Kaithwas
Journal:  3 Biotech       Date:  2020-07-08       Impact factor: 2.406

10.  Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis.

Authors:  Karen K Y Lam; Xingji Zheng; Roberto Forestieri; Aruna D Balgi; Matt Nodwell; Sarah Vollett; Hilary J Anderson; Raymond J Andersen; Yossef Av-Gay; Michel Roberge
Journal:  PLoS Pathog       Date:  2012-05-10       Impact factor: 6.823
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