Literature DB >> 6698205

High resolution proton NMR studies of perfused rat hearts.

K Ugurbil, M Petein, R Maidan, S Michurski, J N Cohn, A H From.   

Abstract

High resolution 1H NMR spectra of perfused rat hearts have been obtained under normoxic, ischemic and hypoxic conditions. Several myocardial metabolites including taurine, carnitine, lactate and tissue glycerides are detected in the 1H NMR spectra. Changes in oxygen availability induce perturbations in the levels of some metabolites, in particular, lactate. Experiments with fasted rats and with substrate-free perfusion suggest that the glycerides detected in 1H spectra are metabolically mobilizable but have a slow rate of turnover. These results demonstrate that utility of 1H NMR in monitoring myocardial metabolism.

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Year:  1984        PMID： 6698205     DOI： 10.1016/0014-5793(84)80835-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission.

Authors:  A Syrota; P Jehenson
Journal:  Eur J Nucl Med       Date:  1991

2.  A 1H NMR technique for observing metabolite signals in the spectrum of perfused liver.

Authors:  T Jue; F Arias-Mendoza; N C Gonnella; G I Shulman; R G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

3.  Early impairment of transmural principal strains in the left ventricular wall after short-term, high-fat feeding of mice predisposed to cardiac steatosis.

Authors:  Janusz H Hankiewicz; Natasha H Banke; Mariam Farjah; E Douglas Lewandowski
Journal:  Circ Cardiovasc Imaging       Date:  2010-09-13       Impact factor: 7.792

4.  Lactate detection in inducible and orthotopic Her2/neu mammary gland tumours in mouse models.

Authors:  S Magnitsky; G K Belka; C Sterner; S Pickup; L A Chodosh; J D Glickson
Journal:  NMR Biomed       Date:  2012-07-05       Impact factor: 4.044

5.  In vivo solvent-suppressed localized hydrogen nuclear magnetic resonance spectroscopy: a window to metabolism?

Authors:  P A Bottomley; W A Edelstein; T H Foster; W A Adams
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

6.  Multinuclear approach to nuclear magnetic resonance investigations in tissue with heteronuclei: 14N, 35Cl, 39K.

Authors:  O Lutz; T Erata; H Förster; D Müller
Journal:  Naturwissenschaften       Date:  1986-02

Review 7.  Cardiac 1H-MR spectroscopy.

Authors:  M von Kienlin
Journal:  MAGMA       Date:  1998-09       Impact factor: 2.533

8.  Interrogation of living myocardium in multiple static deformation states with diffusion tensor and diffusion spectrum imaging.

Authors:  Maelene Lohezic; Irvin Teh; Christian Bollensdorff; Rémi Peyronnet; Patrick W Hales; Vicente Grau; Peter Kohl; Jürgen E Schneider
Journal:  Prog Biophys Mol Biol       Date:  2014-08-10       Impact factor: 3.667

Review 9.  (1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism.

Authors:  Kiterie M E Faller; Craig A Lygate; Stefan Neubauer; Jürgen E Schneider
Journal:  Heart Fail Rev       Date:  2013-09       Impact factor: 4.214
  9 in total

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