| Literature DB >> 6698106 |
C Auriault, M Damonneville, C Verwaerde, R Pierce, M Joseph, M Capron, A Capron.
Abstract
The immunogenicity of molecules shed by schistosomula into culture medium (antigens present in schistosomula-released products, SRP-A) has been studied. The results obtained show that SRP-A preferentially induce an IgE response when injected into rats, without the need for adjuvants. Moreover, anti-SRP-A IgE is cytotoxic in vitro for the larvae in the presence of macrophages, eosinophils or platelets, which have previously been demonstrated as being the three efficient killer cells for schistosomula in the presence of specific IgE. Immunofluorescence analysis locates the target antigens at the schistosomulum surface. Among the antigens recognized by anti-SRP-A IgE, two molecules of 26 and 22 kDa have been identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis followed by western blotting.Entities:
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Year: 1984 PMID： 6698106 DOI： 10.1002/eji.1830140206
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532