Literature DB >> 6697075

Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.

H Isomäki, J Martio, K Kaarela, A Kajander, K Koota, K Lehtinen, R Luukkainen, T Martio, M Nissilä, P Nuotio.   

Abstract

The analgesic effect of 10 anti-inflammatory drugs was compared using a single-blind method in 90 patients with rheumatoid arthritis. Each patient received two different drugs, for three days each and each drug was evaluated in 18 patients. After the trial, the patients considered which of the drugs they preferred. The greatest relief from pain was achieved by diclofenac, indomethacin, naproxen and tolfenamic acid, each of these being preferred by the majority of patients and being significantly (p less than 0.01) better than the least effective drugs ketoprofen and proquazone. Acetylsalicylic acid, azapropazone, carprofen and ibuprofen were considered intermediate in efficacy.

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Year:  1984        PMID: 6697075     DOI: 10.1093/rheumatology/23.1.61

Source DB:  PubMed          Journal:  Br J Rheumatol        ISSN: 0263-7103


  6 in total

1.  Analgesic effect of indomethacin shown using the nociceptive flexion reflex in humans.

Authors:  R Guieu; O Blin; J Pouget; G Serratrice
Journal:  Ann Rheum Dis       Date:  1992-03       Impact factor: 19.103

2.  Evaluation of the analgesic efficacy and safety of carprofen.

Authors:  J E Lindenmuth; M S Clark; G E Fryer
Journal:  Anesth Prog       Date:  1989 Jul-Oct

3.  Orally administered tolfenamic acid inhibits leukotriene synthesis in isolated human peripheral polymorphonuclear leukocytes.

Authors:  E Moilanen; J Alanko; A Juhakoski; H Vapaatalo
Journal:  Agents Actions       Date:  1989-08

4.  Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway.

Authors:  Jun-Hee Kim; Ji-Youn Jung; Jung-Hyun Shim; Jin Kim; Kyeong-Hee Choi; Ji-Ae Shin; Eun-Sun Choi; Syng-Ook Lee; Sudhakar Chintharlapalli; Ki Han Kwon; Dae-Ho Leem; Nam-Pyo Cho; Sung-Dae Cho
Journal:  J Clin Biochem Nutr       Date:  2010-06-17       Impact factor: 3.114

5.  Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.

Authors:  E Seppälä; M Nissilä; H Isomäki; P Nuotio; E Nykänen; O Laitinen; H Vapaatalo
Journal:  Clin Rheumatol       Date:  1985-09       Impact factor: 2.980

6.  Rational use of analgesics in the treatment of the rheumatic disorders.

Authors:  F D Hart
Journal:  Drugs       Date:  1987-01       Impact factor: 9.546

  6 in total

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