Literature DB >> 6697061

Relationship between structure of phenothiazine analogues and their activity on platelet calcium fluxes.

J Enouf, S Lévy-Toledano.   

Abstract

Phenothiazine analogues have been tested for their effect on calcium uptake into platelet membrane vesicles and on ionophore-induced platelet activation, both phenomena being Ca2+-dependent. Both calcium uptake into membrane vesicles and ionophore-induced platelet activation were inhibited by the drugs. Evidence for two inhibitors as potent as chlorpromazine and trifluoperazine was found. These drugs are apparently competitive inhibitors of calcium uptake. A structure-activity relationship has been established. The data suggest that the phenothiazines are able to inhibit calmodulin-insensitive calcium uptake of platelet membrane vesicles and that therefore they cannot be assumed to be selective inhibitors of calmodulin interactions under all circumstances.

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Year:  1984        PMID： 6697061      PMCID： PMC1986848          DOI： 10.1111/j.1476-5381.1984.tb10104.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  29 in total

1.  Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

Authors:  R M Levin; B Weiss
Journal:  Mol Pharmacol       Date:  1977-07       Impact factor: 4.436

2.  THE AGGREGATION OF BLOOD PLATELETS.

Authors:  G V BORN; M J CROSS
Journal:  J Physiol       Date:  1963-08       Impact factor: 5.182

3.  Studies on the mechanism of action of a new Ca-2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles.

Authors:  C Y Chiou; M H Malagodi
Journal:  Br J Pharmacol       Date:  1975-02       Impact factor: 8.739

4.  Calcium and chlorpromazine interactions in rat synaptic plasma membranes. A spin-label and fluorescence probe study.

Authors:  J Breton; J Viret; F Leterrier
Journal:  Arch Biochem Biophys       Date:  1977-03       Impact factor: 4.013

5.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

Review 6.  Movement of calcium ions and their role in the activation of platelets.

Authors:  P Massini; R Käser-Glanzmann; E F Lüscher
Journal:  Thromb Haemost       Date:  1978-10-31       Impact factor: 5.249

7.  Influence of chlorpromazine on calcium movements and contractile responses of guinea-pig ileum longitudinal smooth muscle to agonists.

Authors:  A K Chaturvedi; E J Landon; B V Rama Sastry
Journal:  Arch Int Pharmacodyn Ther       Date:  1978-11

8.  Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate and protein kinase.

Authors:  R Käser-Glanzmann; M Jakäbovä; J N George; E F Lüscher
Journal:  Biochim Biophys Acta       Date:  1977-05-02

9.  Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity.

Authors:  D R Hathaway; R S Adelstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

10.  Evidence that calcium regulates platelet function.

Authors:  T C Detwiler; I F Charo; R D Feinman
Journal:  Thromb Haemost       Date:  1978-10-31       Impact factor: 5.249
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  4 in total

1.  Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells.

Authors:  N Grosman
Journal:  Agents Actions       Date:  1986-03

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Authors:  C Magnier; R Bredoux; T Kovacs; R Quarck; B Papp; E Corvazier; J de Gunzburg; J Enouf
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

3.  The phosphoprotein that regulates platelet Ca2+ transport is located on the plasma membrane, controls membrane-associated Ca2(+)-ATPase and is not glycoprotein Ib beta-subunit.

Authors:  A Darnanville; R Bredoux; K J Clemetson; N Kieffer; N Bourdeau; S Levy-Toledano; J P Caen; J Enouf
Journal:  Biochem J       Date:  1991-01-15       Impact factor: 3.857

Review 4.  The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel.

Authors:  Emre Acaroglu; Regis Bobe; Jocelyn Enouf; Ralph Marcucio; Florina Moldovan; Alain Moreau
Journal:  Eur Spine J       Date:  2012-03-09       Impact factor: 3.134
  4 in total

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