| Literature DB >> 6696773 |
S A Jimenez, A Millan, R I Bashey.
Abstract
Abnormalities in collagen metabolism similar to those occurring in the skin of patients with scleroderma have been demonstrated in the TSK (tight skin) mouse, a dominant mutant of the inbred B10.D2(58N)/SN mouse strain. These abnormalities, which consist of increased collagen content, accelerated biosynthesis, and increased extractibility of the newly synthesized molecules, suggest that the TSK mouse may be an excellent animal model for the study of the connective tissue alterations characteristic of scleroderma.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6696773 DOI： 10.1002/art.1780270209
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591