Literature DB >> 6696740

cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes.

P Arslan, A N Corps, T R Hesketh, J C Metcalfe, T Pozzan.   

Abstract

In intact lymphocytes, linoleic acid acts as a typical mitochondrial uncoupler: it substantially decreases the mitochondrial membrane potential and the cellular ATP level, while stimulating oxygen consumption and glycolysis. Under these conditions the inhibition of cellular functions by linoleic acid cannot be attributed to its postulated effects on lipid domains in the plasma membrane.

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Year:  1984        PMID： 6696740      PMCID： PMC1153232          DOI： 10.1042/bj2170419

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation.

Authors:  D Roos; J A Loos
Journal:  Exp Cell Res       Date:  1973-03-15       Impact factor: 3.905

2.  Effect of monovalent cation ionophores on lymphocyte cellular metabolism.

Authors:  P Arslan; C Montecucco; D Celi; T Pozzan
Journal:  Biochim Biophys Acta       Date:  1981-04-22

3.  Localization of mitochondria in living cells with rhodamine 123.

Authors:  L V Johnson; M L Walsh; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

4.  Cap formation by various ligands on lymphocytes shows the same dependence on high cellular ATP levels.

Authors:  T Pozzan; A N Corps; C Montecucco; T R Hesketh; J C Metcalfe
Journal:  Biochim Biophys Acta       Date:  1980-11-18

5.  Aerobic glycolysis and lymphocyte transformation.

Authors:  D A Hume; J L Radik; E Ferber; M J Weidemann
Journal:  Biochem J       Date:  1978-09-15       Impact factor: 3.857

6.  Model for capping derived from inhibition of surface receptor capping by free fatty acids.

Authors:  R D Klausner; D K Bhalla; P Dragsten; R L Hoover; M J Karnovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

7.  Determination of the mitochondrial protonmotive force in isolated hepatocytes.

Authors:  J B Hoek; D G Nicholls; J R Williamson
Journal:  J Biol Chem       Date:  1980-02-25       Impact factor: 5.157

8.  Lymphocyte membrane potential assessed with fluorescent probes.

Authors:  T J Rink; C Montecucco; T R Hesketh; R Y Tsien
Journal:  Biochim Biophys Acta       Date:  1980

9.  The concept of lipid domains in membranes.

Authors:  M J Karnovsky; A M Kleinfeld; R L Hoover; R D Klausner
Journal:  J Cell Biol       Date:  1982-07       Impact factor: 10.539

10.  Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123.

Authors:  S Goldstein; L B Korczack
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539
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  8 in total

1.  Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo.

Authors:  K Agam; M von Campenhausen; S Levy; H C Ben-Ami; B Cook; K Kirschfeld; B Minke
Journal:  J Neurosci       Date:  2000-08-01       Impact factor: 6.167

2.  Effect of anticoagulants in vitro on the viability of lymphocytes and content of free fatty acids in plasma.

Authors:  A Klein; S Ramcharitar; N Christeff; E Nisbett-Brown; E Nunez; A Malkin
Journal:  In Vitro Cell Dev Biol       Date:  1991-04

3.  Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins.

Authors:  Tatiana Tkatch; Elisa Greotti; Gytis Baranauskas; Diana Pendin; Soumitra Roy; Luliaoana I Nita; Jennifer Wettmarshausen; Matthias Prigge; Ofer Yizhar; Orian S Shirihai; Daniel Fishman; Michal Hershfinkel; Ilya A Fleidervish; Fabiana Perocchi; Tullio Pozzan; Israel Sekler
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-13       Impact factor: 11.205

4.  Biosynthesis of platelet-activating factor (PAF) in human polymorphonuclear leucocytes. The role of lyso-PAF disposal and free arachidonic acid.

Authors:  M C Garcia; S Fernandez-Gallardo; M A Gijon; C Garcia; M L Nieto; M Sanchez Crespo
Journal:  Biochem J       Date:  1990-05-15       Impact factor: 3.857

5.  The effects of mitochondrial energetics inhibitors on the fluorescence of potential-sensitive dyes rhodamine 123 and diS-C3-(5) in lymphocyte suspensions.

Authors:  E N Mokhova; I A Rozovskaya
Journal:  J Bioenerg Biomembr       Date:  1986-08       Impact factor: 2.945

Review 6.  Insights on TRP channels from in vivo studies in Drosophila.

Authors:  Baruch Minke; Moshe Parnas
Journal:  Annu Rev Physiol       Date:  2006       Impact factor: 19.318

7.  Energy thresholds that determine membrane integrity and injury in a renal epithelial cell line (LLC-PK1). Relationships to phospholipid degradation and unesterified fatty acid accumulation.

Authors:  M A Venkatachalam; Y J Patel; J I Kreisberg; J M Weinberg
Journal:  J Clin Invest       Date:  1988-03       Impact factor: 14.808

8.  Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C.

Authors:  P F Weller; S W Ryeom; S T Picard; S J Ackerman; A M Dvorak
Journal:  J Cell Biol       Date:  1991-04       Impact factor: 10.539
  8 in total

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