| Literature DB >> 6695622 |
P J de Jong, J P Lakke, A W Teelken.
Abstract
CSF levels of GABA were investigated in a group of Parkinson patients without drug treatment and a group of Parkinson patients under treatment with L-DOPA or anticholinergics. Probenecid results in an elevation of CSF GABA levels in healthy persons. The results indicate a significant decrease of GABA levels in CSF in untreated Parkinson patients. Parkinson patients treated with L-DOPA or anticholinergics show nearly normal CSF GABA levels. This may suggest that the altered GABA function in Parkinson's disease is secondary to changes in the dopamine system.Entities:
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Year: 1984 PMID： 6695622
Source DB: PubMed Journal: Adv Neurol ISSN： 0091-3952