| Literature DB >> 6695410 |
H Weber, J C Lamb, M W Harris, J A Moore.
Abstract
Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is teratogenic in 100% of the fetuses at dose levels that are not maternally toxic. The fetal kidney is the most sensitive target organ but the kidney lesions may be reversible.Entities:
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Year: 1984 PMID： 6695410 DOI： 10.1016/0378-4274(84)90145-0
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372