Literature DB >> 6695185

The malaria parasite monitored by photoacoustic spectroscopy.

D Balasubramanian, C Mohan Rao, B Panijpan.   

Abstract

Noninvasive photoacoustic spectroscopy was used to study the malaria parasites Plasmodium chabaudi and Plasmodium berghei, their pigment, and ferriprotoporphyrin IX, which is a by-product of the hemoglobin that the parasite ingests. The results indicate that the pigment consists of ferriprotophorphyrin self-aggregates and a noncovalent complex of ferriprotoporphyrin and protein. Spectra of chloroquine-treated parasites reveal in situ interaction between the drug and ferriprotoporphyrin. Chloroquine-resistant parasites, readily distinguishable by this method, appear to degrade hemoglobin only partially.

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Year:  1984        PMID： 6695185     DOI： 10.1126/science.6695185

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  Mechanism of malarial haem detoxification inhibition by chloroquine.

Authors:  A V Pandey; H Bisht; V K Babbarwal; J Srivastava; K C Pandey; V S Chauhan
Journal:  Biochem J       Date:  2001-04-15       Impact factor: 3.857

Review 2.  Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.

Authors:  Christine F Markwalter; Andrew G Kantor; Carson P Moore; Kelly A Richardson; David W Wright
Journal:  Chem Rev       Date:  2018-12-04       Impact factor: 60.622

3.  Depth profiling of mammalian cells by photoacoustic spectroscopy: localization of ligands.

Authors:  K Narayanan; S Chandani; T Ramakrishna; C M Rao
Journal:  Biophys J       Date:  1997-05       Impact factor: 4.033

4.  On the molecular mechanism of chloroquine's antimalarial action.

Authors:  D J Sullivan; I Y Gluzman; D G Russell; D E Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

5.  Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum.

Authors:  N Surolia; G Padmanaban
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 6.  Malarial hemozoin: from target to tool.

Authors:  Lorena M Coronado; Christopher T Nadovich; Carmenza Spadafora
Journal:  Biochim Biophys Acta       Date:  2014-02-17

7.  Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria.

Authors:  Ekaterina Y Lukianova-Hleb; Kelly M Campbell; Pamela E Constantinou; Janet Braam; John S Olson; Russell E Ware; David J Sullivan; Dmitri O Lapotko
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-30       Impact factor: 11.205

8.  A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes.

Authors:  Roxanne Openshaw; Keletso Maepa; Stefan J Benjamin; Lauren Wainwright; Jill M Combrinck; Roger Hunter; Timothy J Egan
Journal:  ACS Infect Dis       Date:  2021-01-12       Impact factor: 5.084

9.  Computational investigation on the photoacoustics of malaria infected red blood cells.

Authors:  Ratan K Saha; Subhajit Karmakar; Madhusudan Roy
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240

10.  Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.

Authors:  M Mungthin; P G Bray; R G Ridley; S A Ward
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191
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