Literature DB >> 6694216

Intercalating drugs and low temperatures inhibit synthesis and processing of ribosomal RNA in isolated human mitochondria.

G Gaines, G Attardi.   

Abstract

Mitochondrial DNA transcription in isolated HeLa cell mitochondria faithfully reproduces the in vivo process. In this system, actinomycin D, proflavine and ethidium bromide preferentially inhibit the formation of ribosomal RNA over that of messenger RNA, strongly supporting independent controls of the two overlapping transcription units involved in their synthesis. The processing step removing the tRNAPhe sequence at the 5' end of the ribosomal RNA precursor is uniquely sensitive to low temperature, proflavine and ethidium bromide.

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Year:  1984        PMID： 6694216     DOI： 10.1016/s0022-2836(84)80017-0

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  22 in total

1.  A chemical enucleation method for the transfer of mitochondrial DNA to rho(o) cells.

Authors:  Maria Pilar Bayona-Bafaluy; Giovanni Manfredi; Carlos T Moraes
Journal:  Nucleic Acids Res       Date:  2003-08-15       Impact factor: 16.971

2.  Autonomously replicating RNA in mitochondria of maize plants with S-type cytoplasm.

Authors:  P M Finnegan; G G Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

3.  Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria.

Authors:  Alexandre Smirnov; Ivan Tarassov; Anne-Marie Mager-Heckel; Michel Letzelter; Robert P Martin; Igor A Krasheninnikov; Nina Entelis
Journal:  RNA       Date:  2008-02-26       Impact factor: 4.942

4.  Variation in protein and RNA synthesis activity in isolated mitochondria of the developing rice (Oryza sativa L.) panicle.

Authors:  H Dai; Y S Lo; T S Wang; K S Chiang
Journal:  Theor Appl Genet       Date:  1995-06       Impact factor: 5.699

5.  The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions.

Authors:  P Fernandez-Silva; F Martinez-Azorin; V Micol; G Attardi
Journal:  EMBO J       Date:  1997-03-03       Impact factor: 11.598

6.  The excised leader of human cytochrome c oxidase subunit I mRNA which contains the origin of mitochondrial DNA light-strand synthesis accumulates in mitochondria and is polyadenylated.

Authors:  G Gaines; C Rossi; G Attardi
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

7.  Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans.

Authors:  Anthony L Luz; Joel N Meyer
Journal:  Mitochondrion       Date:  2016-08-23       Impact factor: 4.160

8.  RNA mapping on Drosophila mitochondrial DNA: precursors and template strands.

Authors:  F Berthier; M Renaud; S Alziari; R Durand
Journal:  Nucleic Acids Res       Date:  1986-06-11       Impact factor: 16.971

9.  Nucleotides flanking the promoter sequence influence the transcription of the yeast mitochondrial gene coding for ATPase subunit 9.

Authors:  T K Biswas; G S Getz
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

10.  Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.

Authors:  Anne K Hyvärinen; Mona K Kumanto; Sanna K Marjavaara; Howard T Jacobs
Journal:  BMC Mol Biol       Date:  2010-09-16       Impact factor: 2.946
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