| Literature DB >> 6694172 |
B B Jarvis, J O Midiwo, E P Mazzola.
Abstract
Various 8 beta-hydroxy, 16-hydroxy, and 9 beta,10 beta-epoxy derivatives of roridins A and H and verrucarins A and J have been prepared and tested in vivo against P388 mouse leukemia. The 9 beta,10 beta-epoxy derivatives and 16-hydroxy derivatives consistently exhibit very high activity. The 8 beta-hydroxy-9 beta,10 beta-epoxy and 16-hydroxy-9 beta,10 beta-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary activity against P388. The 8 beta-hydroxy-9 beta,10 beta-epoxy and 16-hydroxy-9 beta,10 beta-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary against P388.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6694172 DOI： 10.1021/jm00368a025
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446