Literature DB >> 6693492

Organization of acetylcholine receptor clusters in cultured rat myotubes is calcium dependent.

S Bursztajn, J L McManaman, S H Appel.   

Abstract

The effect of extracellular Ca2+ concentration and myasthenic globulin on the distribution and appearance of acetylcholine receptor (AChR) clusters on rat myotubes was studied with tetramethyl-rhodamine-labeled alpha BTX. Low Ca2+ medium (2.5 X 10(-5) M) caused a time-dependent loss of AChR clusters, and a concomitant increase in small punctate areas of fluorescence. High Ca2+ concentrations (1.5 X 10(-2) M) increased the size of AChR clusters without altering AChR synthesis. These changes were not observed with other divalent ions. In the presence of myasthenic globulin, the rate of AChR turnover increases, and AChR clusters are rapidly dispersed. High Ca2+ concentration partially protects the AChR clusters from dispersal and decreases the rate of receptor turnover.

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Year:  1984        PMID： 6693492      PMCID： PMC2113093          DOI： 10.1083/jcb.98.2.507

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  37 in total

1.  Inhibitors of membrane depolarization regulate acetylcholine receptor synthesis by a calcium-dependent, cyclic nucleotide-independent mechanism.

Authors:  J L McManaman; J C Blosser; S H Appel
Journal:  Biochim Biophys Acta       Date:  1982-02-10

2.  Myasthenic patients' IgG causes redistribution of acetylcholine receptors: freeze-fracture studies.

Authors:  D W Pumplin; D B Drachman
Journal:  J Neurosci       Date:  1983-03       Impact factor: 6.167

3.  The effects of electrical inactivity and denervation on the distribution of acetylcholine receptors in developing rat muscle.

Authors:  L Ziskind-Conhaim; J I Bennett
Journal:  Dev Biol       Date:  1982-03       Impact factor: 3.582

4.  Membrane lipid heterogeneity associated with acetylcholine receptor particle aggregates in Xenopus embryonic muscle cells.

Authors:  P C Bridgman; Y Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

5.  Diffusely distributed acetylcholine receptors can participate in cluster formation on cultured rat myotubes.

Authors:  M Stya; D Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

6.  Myasthenic globulin enhances the loss of acetylcholine receptor clusters.

Authors:  S Bursztajn; J L McManaman; S B Elias; S H Appel
Journal:  Science       Date:  1983-01-14       Impact factor: 47.728

7.  The effect of calcium on acetylcholine receptor synthesis.

Authors:  J L McManaman; J C Blosser; S H Appel
Journal:  J Neurosci       Date:  1981-07       Impact factor: 6.167

8.  Cytoplasmic actin in postsynaptic structures at the neuromuscular junction.

Authors:  Z W Hall; B W Lubit; J H Schwartz
Journal:  J Cell Biol       Date:  1981-09       Impact factor: 10.539

9.  Absence of filipin-sterol complexes from the membranes of active zones and acetylcholine receptor aggregates at frog neuromuscular junctions.

Authors:  Y Nakajima; P C Bridgman
Journal:  J Cell Biol       Date:  1981-02       Impact factor: 10.539

10.  Evidence that coated vesicles transport acetylcholine receptors to the surface membrane of chick myotubes.

Authors:  S Bursztajn; G D Fischbach
Journal:  J Cell Biol       Date:  1984-02       Impact factor: 10.539
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  9 in total

1.  Coated and smooth vesicles participate in acetylcholine receptor transport.

Authors:  S Bursztajn; H B Nudleman; S A Berman
Journal:  Cell Tissue Res       Date:  1987-06       Impact factor: 5.249

2.  Calcium and ionophore A23187 stimulates deposition of extracellular matrix and acetylcholinesterase release in cultured myotubes.

Authors:  S Bursztajn; L W Schneider; Y J Jong; S A Berman
Journal:  Cell Tissue Res       Date:  1991-07       Impact factor: 5.249

3.  Induction of phosphorylation and cell surface redistribution of acetylcholine receptors by phorbol ester and carbamylcholine in cultured chick muscle cells.

Authors:  A Ross; M Rapuano; J Prives
Journal:  J Cell Biol       Date:  1988-09       Impact factor: 10.539

4.  Insertion and internalization of acetylcholine receptors at clustered and diffuse domains on cultured myotubes.

Authors:  S Bursztajn; S A Berman; J L McManaman; M L Watson
Journal:  J Cell Biol       Date:  1985-07       Impact factor: 10.539

5.  Cytoplasmic components of acetylcholine receptor clusters of cultured rat myotubes: the 58-kD protein.

Authors:  R J Bloch; W G Resneck; A O'Neill; J Strong; D W Pumplin
Journal:  J Cell Biol       Date:  1991-10       Impact factor: 10.539

6.  Clusters of neural cell adhesion molecule at sites of cell-cell contact.

Authors:  R J Bloch
Journal:  J Cell Biol       Date:  1992-01       Impact factor: 10.539

7.  Disruption and reformation of the acetylcholine receptor clusters of cultured rat myotubes occur in two distinct stages.

Authors:  D W Pumplin; R J Bloch
Journal:  J Cell Biol       Date:  1987-01       Impact factor: 10.539

8.  An unusual beta-spectrin associated with clustered acetylcholine receptors.

Authors:  R J Bloch; J S Morrow
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539

9.  Formation of acetylcholine receptor clusters in chick myotubes: migration or new insertion?

Authors:  J M Dubinsky; D J Loftus; G D Fischbach; E L Elson
Journal:  J Cell Biol       Date:  1989-10       Impact factor: 10.539
  9 in total

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