Literature DB >> 6692893

Evaluation of monoaminergic receptors in the genetically epilepsy prone rat.

K H Ko, J W Dailey, P C Jobe.   

Abstract

The intensity of sound-induced convulsions in the genetically epilepsy-prone rat (GEPR) was reduced in a dose related fashion by intracerebroventricular administration of dobutamine, (beta 1 agonist), terbutaline (beta 2 agonist) or phenylephrine (alpha 1 agonist). BHT-920 (alpha 2 agonist) did not cause a dose-related decrease in sound-induced convulsion intensity. Binding studies showed that whole brain alpha and beta receptor densities (Bmax) were normal while the Kd was increased for the beta ligand in GEPR brain.

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Year:  1984        PMID： 6692893     DOI： 10.1007/bf01959107

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  19 in total

Review 1.  Regulation of noradrenaline release by presynaptic receptor systems.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

2.  A study of the adrenotropic receptors.

Authors:  R P AHLQUIST
Journal:  Am J Physiol       Date:  1948-06

3.  Direct evidence of two types of beta adrenoceptor binding site in lung tissue.

Authors:  D B Barnett; E L Rugg; S R Nahorski
Journal:  Nature       Date:  1978-05-11       Impact factor: 49.962

4.  Effect of neonatal 6-hydroxydopamine treatment on audiogenic seizures.

Authors:  W M Bourn; L Chin; A L Picchioni
Journal:  Life Sci       Date:  1977-09-01       Impact factor: 5.037

5.  [Effect of agents, changing the monoamine level, on audiogenic epileptic seizures in rats].

Authors:  I B Prakh'e
Journal:  Biull Eksp Biol Med       Date:  1973-09

6.  Role of brain 5-hydroxytryptamine in audiogenic seizure in the rat.

Authors:  P C Jobe; A L Picchioni; L Chin
Journal:  Life Sci       Date:  1973-07-01       Impact factor: 5.037

7.  Role of brain norepinephrine in audiogenic seizure in the rat.

Authors:  P C Jobe; A L Picchioni; L Chin
Journal:  J Pharmacol Exp Ther       Date:  1973-01       Impact factor: 4.030

8.  The pharmacological differentiation of adrenergic receptors.

Authors:  R F Furchgott
Journal:  Ann N Y Acad Sci       Date:  1967-02-10       Impact factor: 5.691

Review 9.  Alpha-adrenoceptor subclassification.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1981       Impact factor: 5.545

10.  Abnormalities in monoamine levels in the central nervous system of the genetically epilepsy-prone rat.

Authors:  P C Jobe; H E Laird; K H Ko; T Ray; J W Dailey
Journal:  Epilepsia       Date:  1982-08       Impact factor: 5.864
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  3 in total

Review 1.  The role of the central noradrenergic system in behavioral inhibition.

Authors:  Eric A Stone; Yan Lin; Yasmeen Sarfraz; David Quartermain
Journal:  Brain Res Rev       Date:  2011-03-05

Review 2.  Rhythm and blues: animal models of epilepsy and depression comorbidity.

Authors:  S Alisha Epps; David Weinshenker
Journal:  Biochem Pharmacol       Date:  2012-08-23       Impact factor: 5.858

3.  Mechanisms of Psychiatric Comorbidities in Epilepsy.

Authors:  Jamie Maguire
Journal:  Curr Top Behav Neurosci       Date:  2022
  3 in total

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