Literature DB >> 6692599

IgA- and insulin-containing (C3-fixing) circulating immune complexes in diabetes mellitus.

G Triolo, E Giardina, A Rinaldi, G D Bompiani.   

Abstract

Sera of patients with type 1 and type 2 diabetes were examined for IgA- and insulin-containing immune complexes (IgA-ICs, ICs-insulin) using a solid-phase anti-C3 enzyme immunoassay. IgM-ICs and IgG-ICs were also investigated. IgA-ICs were detected in 6 of 26 type 1 diabetics, in 9 of 25 insulin-treated type 2 diabetics, and in 8 of 34 type 2 diabetics on oral hypoglycemic agents, but only in 2 sex- and age-matched controls. ICs-insulin was detected in 9 of 25 type 1 diabetics and in 1 of 19 insulin-treated type 2 diabetics, irrespective of the time of insulin treatment. ICs-insulin did not appear to be related to the presence of microangiopathy. IgA-ICs were found to be associated with the presence of microangiopathy, suggesting that they may play a role in the pathogenesis of the late diabetic complications.

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Year:  1984        PMID： 6692599     DOI： 10.1016/0090-1229(84)90051-5

Source DB:  PubMed          Journal:  Clin Immunol Immunopathol        ISSN： 0090-1229


  7 in total

1.  Detection of the terminal fluid-phase complement complex, SC5b-9, in the plasma of patients with insulin-dependent (type I) diabetes mellitus. Relation to increased urinary albumin excretion and plasma von Willebrand factor.

Authors:  G Triolo; E Giardina; D Casiglia; G Scarantino; G D Bompiani
Journal:  Clin Exp Immunol       Date:  1991-04       Impact factor: 4.330

2.  C3-containing serum immune complexes in patients with systemic lupus erythematosus: correlation to disease activity and comparison with other rheumatic diseases.

Authors:  C Huber; A Rüger; M Herrmann; F Krapf; J R Kalden
Journal:  Rheumatol Int       Date:  1989       Impact factor: 2.631

3.  Comparative studies on immunoglobulins, complement component (C3), albumin, and immunoglobulin A-containing circulating immune complexes in serum and bile of patients with biliary obstruction.

Authors:  G Ohshio; F Furukawa; T Manabe; T Tobe; Y Hamashima
Journal:  Dig Dis Sci       Date:  1988-05       Impact factor: 3.199

4.  IgA containing circulating immune complexes and IgA anti-single stranded DNA antibodies in patients with obstructive jaundice.

Authors:  G Ohshio; F Furukawa; K Sekita; T Manabe; T Tobe; Y Hamashima
Journal:  Clin Exp Immunol       Date:  1985-02       Impact factor: 4.330

5.  Clinical significance of U1-RNP immune complexes in mixed connective tissue disease and systemic lupus erythematosus.

Authors:  N Negoro; Y Kanayama; T Takeda; K Amatsu; S Koda; Y Inoue; T Kim; M Okamura; T Inoue
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631

6.  Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus.

Authors:  M T Kasaian; H Ikematsu; J E Balow; P Casali
Journal:  J Immunol       Date:  1994-03-15       Impact factor: 5.422

7.  Contribution of secretory IgA, polymeric IgA and IgA/secretory component-containing circulating immune complexes to the serum hyper-IgA in diabetes mellitus.

Authors:  G Triolo; E Giardina; M R Zarcone; C Giordano; A Rinaldi; G D Bompiani
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122
  7 in total

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