| Literature DB >> 6692342 |
I Hirono, K Yamada, H Niwa, Y Shizuri, M Ojika, S Hosaka, T Yamaji, K Wakamatsu, H Kigoshi, K Niiyama.
Abstract
Isolation of the carcinogen in the boiling water extract of bracken fern was conducted by following the active principle with a carcinogenicity bioassay. Fractionation of the bracken extract was carried out using adsorption on resin (Amberlite XAD-2 and TOYOPEARL HW-40 (c] and organic solvent extraction. A diet containing each of the fractions was given to 7 female Charles River Sprague-Dawley rats (CD rats) of 4 weeks old, except for the second fraction. All 7 rats given the last carcinogenic fraction developed mammary and intestinal tumors and 5 rats had urinary bladder tumors. Ptaquiloside (PT) which induced mammary cancer in female CD rats and rho-hydroxystyrene glycosides were isolated from this fraction.Entities:
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Year: 1984 PMID： 6692342 DOI： 10.1016/0304-3835(84)90001-6
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679