Improvement in injury induced hypocalcia by high-dose naloxone intervention.

Naloxone hydrochloride was used to re-establish normal calcium activities in the extracellular space of the injured spinal cord. The micromolar levels of calcium which occur immediately after injury were improved above control values by 1 h 30 min post-injury; normal activities occurred at 2 h 45 min. Such a restitution of ionic levels after injury may contribute to the beneficial effects of naloxone in traumatic injury.