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Literature DB >> 669075

Stimulation of non-parietal cell secretion in canine Heidenhain pouches by 16,16-dimethyl prostaglandin E2.

Abstract

The permeability effects of topical and intravenous prostaglandin E2 (PGE2) and 16,16-dimethyl prostaglandin E2 (16DM) were studied in canine Heidenhain pouches using an acid-free perfusate, and changes in volume and HCO-3 content of the perfusate were measured. Topical and intravenous 16DM increased the apparent flux of Na+ and Cl-, and stimulated the secretion of fluid containing HCO-3. 16DM stimulates non-parietal cell secretion and therefore the movement of Na+ cannot be interpreted as passive flux in response to changes in permeability.

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Year: 1978 PMID： 669075 DOI： 10.1159/000198122

Source DB: PubMed Journal: Digestion ISSN： 0012-2823 Impact factor: 3.216

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Cited

14 in total

1. Mechanisms of protective activity of 16,16-dimethyl PGE2 and acetazolamide on gastric and duodenal lesions in rats.

Authors: K Takeuchi; H Ohtsuki; S Okabe
Journal: Dig Dis Sci Date: 1986-04 Impact factor: 3.199

2. Gastric juice electrolyte secretion in conscious dogs with gastric fistulae and its modification by FPL 52694, a mast cell stabilizing agent.

Authors: S P Canfield; B P Curwain
Journal: Br J Pharmacol Date: 1983-11 Impact factor: 8.739

3. A comparison of the effects of prostacyclin and the 15(S), 15-methyl analogs of PGE2 and PGF2-alpha on gastric parietal and nonparietal secretion.

Authors: P T Shea-Donohue; D Nompleggi; L Myers; A Dubois
Journal: Dig Dis Sci Date: 1982-01 Impact factor: 3.199

10. Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non-parietal secretion in the cat.

Authors: A D Gascoigne; B H Hirst
Journal: J Physiol Date: 1981-07 Impact factor: 5.182

Stimulation of non-parietal cell secretion in canine Heidenhain pouches by 16,16-dimethyl prostaglandin E2.

1. Mechanisms of protective activity of 16,16-dimethyl PGE2 and acetazolamide on gastric and duodenal lesions in rats.

2. Gastric juice electrolyte secretion in conscious dogs with gastric fistulae and its modification by FPL 52694, a mast cell stabilizing agent.

3. A comparison of the effects of prostacyclin and the 15(S), 15-methyl analogs of PGE2 and PGF2-alpha on gastric parietal and nonparietal secretion.

Review 4. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.

5. Diflunisal protects human gastric mucosa against damage by indomethacin.

6. Prevention of aspirin-induced faecal blood loss by prostaglandin E2.

7. Topical 16,16-dimethyl-prostaglandin E2. Effects on gastric morphology, hydrogen ion loss, and bicarbonate secretion.

8. Reduction of aspirin-induced fecal blood loss with low-dose misoprostol tablets in man.

9. Gastric bicarbonate appearance with ethanol ingestion. Mechanism and significance.

10. Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non-parietal secretion in the cat.