Literature DB >> 6690425

Regulatory mutants of Streptomyces clavuligerus affected in free diaminopimelic acid content and antibiotic biosynthesis.

Y Aharonowitz, S Mendelovitz, F Kirenberg, V Kuper.   

Abstract

The composition of intracellular free amino acid pools was determined in Streptomyces clavuligerus mutants possessing an altered aspartokinase which is insensitive to concerted feedback inhibition by threonine and lysine. These mutants contained total free amino acid pool contents that were considerably higher than those found in the wild-type strain. Diaminopimelic acid accounted for 10 to 20% of the total free amino acid pools, depending on the individual mutant and its culture growth phase, whereas diaminopimelic acid contained in the wild-type strain accounted for only 0.5% of the total free amino acid pool.

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Year:  1984        PMID： 6690425      PMCID： PMC215184          DOI： 10.1128/jb.157.1.337-340.1984

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

1.  The isolation and characterization of auzotrophs of the aspartic acid family from Streptomyces lipmanii.

Authors:  J R Kirkpatrick; O W Godfrey
Journal:  Folia Microbiol (Praha)       Date:  1973       Impact factor: 2.099

2.  Genetically desensitized aspartate kinase to the concerted feedback inhibition in Brevibacterium flavum.

Authors:  I Shiio; R Miyajima; K Sano
Journal:  J Biochem       Date:  1970-11       Impact factor: 3.387

Review 3.  Control of antibiotic biosynthesis.

Authors:  J F Martin; A L Demain
Journal:  Microbiol Rev       Date:  1980-06

Review 4.  Effect of primary metabolites on secondary metabolism.

Authors:  S W Drew; A L Demain
Journal:  Annu Rev Microbiol       Date:  1977       Impact factor: 15.500

5.  Regulation of cephamycin C synthesis, aspartokinase, dihydrodipicolinic acid synthetase, and homoserine dehydrogenase by aspartic acid family amino acids in Streptomyces clavuligerus.

Authors:  S Mendelovitz; Y Aharonowitz
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

6.  Rapid differentiation of Streptomyces from Nocardia by liquid chromatography.

Authors:  P A Tisdall; J P Anhalt
Journal:  J Clin Microbiol       Date:  1979-10       Impact factor: 5.948

7.  Incorporation of labeled precursors into A16886B, a novel -lactam antibiotic produced by Streptomyces clavuligerus.

Authors:  J G Whitney; D R Brannon; J A Mabe; K J Wicker
Journal:  Antimicrob Agents Chemother       Date:  1972-03       Impact factor: 5.191

8.  beta-lactam antibiotic production by Streptomyces clavuligerus mutants impaired in regulation of aspartokinase.

Authors:  S Mendelovitz; Y Aharonowitz
Journal:  J Gen Microbiol       Date:  1983-07

9.  Isolation of regulatory mutants of the aspartic and pyruvic acid families and their effect on antibiotic production in Streptomyces lipmanii.

Authors:  O W Godfrey
Journal:  Antimicrob Agents Chemother       Date:  1973-08       Impact factor: 5.191

10.  Lysine biosynthesis in Streptomyces lipmanii: implications in antibiotic biosynthesis.

Authors:  J R Kirkpatrick; L E Doolin; O W Godfrey
Journal:  Antimicrob Agents Chemother       Date:  1973-11       Impact factor: 5.191
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  2 in total

1.  Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.

Authors:  Gülay Özcengiz; Sezer Okay; Eser Ünsaldı; Bilgin Taşkın; Paloma Liras; Jacqueline Piret
Journal:  Bioeng Bugs       Date:  2010-01-11

2.  Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis.

Authors:  L H Malmberg; W S Hu; D H Sherman
Journal:  J Bacteriol       Date:  1993-11       Impact factor: 3.490
  2 in total

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