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Literature DB >> 6690416

Indomethacin promotes differentiation of Trypanosoma brucei.

R M Jack, S J Black, S L Reed, C E Davis.

Abstract

The treatment of mice with indomethacin lowered Trypanosoma brucei parasitemia 1 to 2 log10 because it quickly promoted the differentiation of rapidly dividing long, slender trypanosomes into short, stumpy forms that do not divide in the mammal but do develop a functional mitochondrion and the ability to infect the tsetse. Since natural resistance correlates with the rate of differentiation, this observation may provide important information about factors that control the severity of trypanosomiasis.

Entities: Chemical Disease Species

Mesh：

Substances：
Indomethacin

Year: 1984 PMID： 6690416 PMCID： PMC263462 DOI： 10.1128/iai.43.1.445-448.1984

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. II. The number and morphology of the trypano-somes present in the blood of the host at the time of the infected feed.

Authors: D J WIJERS; K C WILLETT
Journal: Ann Trop Med Parasitol Date: 1960-10

Review 2. Indomethacin--a calcium antagonist.

Authors: B J Northover
Journal: Gen Pharmacol Date: 1977

3. Immunosuppression in Trypanosoma brucei infections in rats and mice.

Authors: G M Urquhart; M Murray; P K Murray; F W Jennings; E Bate
Journal: Trans R Soc Trop Med Hyg Date: 1973 Impact factor: 2.184

4. Drugs which inhibit prostaglandin biosynthesis.

Authors: R J Flower
Journal: Pharmacol Rev Date: 1974-03 Impact factor: 25.468

5. Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.

Authors: S M Lanham; D G Godfrey
Journal: Exp Parasitol Date: 1970-12 Impact factor: 2.011

6. Inhibition by non-steroidal anti-inflammatory agents of the ascorbate-induced elevations of platelet cyclic AMP levels.

Authors: W C Pickett; K F Austen; E J Goetzl
Journal: J Cyclic Nucleotide Res Date: 1979

2. Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase.

Authors: F Bringaud; D Baltz; T Baltz
Journal: Proc Natl Acad Sci U S A Date: 1998-07-07 Impact factor: 11.205

3. Role of the long slender to short stumpy transition in the life cycle of the african trypanosomes.

Authors: John Richard Seed; Mary Anne Wenck
Journal: Kinetoplastid Biol Dis Date: 2003-06-25

3 in total

Indomethacin promotes differentiation of Trypanosoma brucei.

1. Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. II. The number and morphology of the trypano-somes present in the blood of the host at the time of the infected feed.

Review 2. Indomethacin--a calcium antagonist.

3. Immunosuppression in Trypanosoma brucei infections in rats and mice.

4. Drugs which inhibit prostaglandin biosynthesis.

5. Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.

6. Inhibition by non-steroidal anti-inflammatory agents of the ascorbate-induced elevations of platelet cyclic AMP levels.

7. Adenosine 3',5'-monophosphate in reproducing and differentiated trypanosomes.

8. Host-parasite interactions which influence the virulence of Trypanosoma (Trypanozoon) brucei brucei organisms.

9. Humoral responses against Trypanosoma brucei variable surface antigen are induced by degenerating parasites.

10. Cyclic 3',5'-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat.

1. The trypanosome surface glycoprotein procyclin is expressed only on tsetse fly vector stages of the parasite.

2. Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase.

3. Role of the long slender to short stumpy transition in the life cycle of the african trypanosomes.