Literature DB >> 6689696

Effects of dichloroacetate on brain pyruvate dehydrogenase.

E Abemayor, G B Kovachich, N Haugaard.   

Abstract

The action of dichloroacetate (DCA) on pyruvate dehydrogenase (PDH) activity of rat brain has been studied in vitro and in vivo. In a crude brain mitochondrial fraction, DCA inhibits PDH kinase and in rat brain slices this compound increases PDH activity and stimulates glucose oxidation. In the whole animal, intraperitoneal injection of DCA causes activation of brain PDH, indicating that this inhibitor crosses the blood-brain barrier. The same treatment with DCA also produced a large increase in heart PDH activity. Further studies of the effects of DCA on the CNS should lead to results of considerable importance.

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Year:  1984        PMID： 6689696     DOI： 10.1111/j.1471-4159.1984.tb09694.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  13 in total

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Authors:  Y Kuroda; M Ito; K Toshima; E Takeda; E Naito; T J Hwang; T Hashimoto; M Miyao; M Masuda; K Yamashita
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2.  Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes.

Authors:  R G Hansford; F Castro
Journal:  Biochem J       Date:  1985-04-01       Impact factor: 3.857

3.  Dichloroacetate increases glucose use and decreases lactate in developing rat brain.

Authors:  A L Miller; J P Hatch; T J Prihoda
Journal:  Metab Brain Dis       Date:  1990-12       Impact factor: 3.584

4.  Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo.

Authors:  Yoshiaki Itoh; Takanori Esaki; Kazuaki Shimoji; Michelle Cook; Mona J Law; Elaine Kaufman; Louis Sokoloff
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-31       Impact factor: 11.205

5.  The effect of 2-oxoglutarate or 3-hydroxybutyrate on pyruvate dehydrogenase complex in isolated cerebrocortical mitochondria.

Authors:  J C Lai; K F Sheu
Journal:  Neurochem Res       Date:  1987-08       Impact factor: 3.996

6.  Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.

Authors:  Robert T Wicks; Javad Azadi; Antonella Mangraviti; Irma Zhang; Lee Hwang; Avadhut Joshi; Hansen Bow; Marianne Hutt-Cabezas; Kristin L Martin; Michelle A Rudek; Ming Zhao; Henry Brem; Betty M Tyler
Journal:  Neuro Oncol       Date:  2014-07-22       Impact factor: 12.300

7.  Dichloroacetate induces apoptosis in endometrial cancer cells.

Authors:  Jason Y Y Wong; Gordon S Huggins; Marcella Debidda; Nikhil C Munshi; Immaculata De Vivo
Journal:  Gynecol Oncol       Date:  2008-04-18       Impact factor: 5.482

8.  Effect of dichloroacetate on acetyl-CoA content and acetylcholine synthesis in rat brain synaptosomes.

Authors:  A Szutowicz; H Bielarczyk; H Skulimowska
Journal:  Neurochem Res       Date:  1994-09       Impact factor: 3.996

9.  Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

Authors:  Ernesto Miquel; Adriana Cassina; Laura Martínez-Palma; Carmen Bolatto; Emiliano Trías; Mandi Gandelman; Rafael Radi; Luis Barbeito; Patricia Cassina
Journal:  PLoS One       Date:  2012-04-03       Impact factor: 3.240

10.  Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation.

Authors:  Yu Duan; Xin Zhao; Wei Ren; Xin Wang; Ke-Fu Yu; Dan Li; Xuan Zhang; Qiang Zhang
Journal:  Onco Targets Ther       Date:  2013-03-14       Impact factor: 4.147
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