Literature DB >> 6689280

Enhanced antitumor activity of adriamycin in combination with allopurinol.

H S Schwartz.   

Abstract

Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin.

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Year:  1983        PMID： 6689280     DOI： 10.1016/0304-3835(83)90189-1

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  3 in total

1.  Pharmacokinetics of adriamycin, adriamycinol, and antipyrine in patients with moderate tumor involvement of the liver.

Authors:  R Preiss; M Matthias; R Sohr; B Brockmann; H Hüller
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

2.  Encapsulation of adriamycin in human erythrocytes.

Authors:  A De Flora; U Benatti; L Guida; E Zocchi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

Review 3.  A chemical perspective on the anthracycline antitumor antibiotics.

Authors:  B R Abdella; J Fisher
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031
  3 in total

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