| Literature DB >> 6689123 |
A W Wood, R L Chang, M T Huang, M Uskokovic, A H Conney.
Abstract
The effect of topical application of 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25-(OH)2D3) on the promotional phase of skin tumor formation in mice was evaluated using 7,12-dimethylbenz [a] anthracene as the tumor initiator and 12-0-tetradecanoylphorbol-13-acetate (TPA) as the tumor promoter. Fifteen weeks of twice weekly topical application of 1 alpha, 25-(OH)2D3 1 hour prior to topical treatment with 16 nmol of TPA inhibited tumor formation in a dose-dependent manner. Doses of 0.25-0.50 nmol of the vitamin D3 metabolite inhibited tumor formation approximately 50% and had no significant effect on the survival or weight gain of the mice. These results indicate that in addition to maintaining calcium homeostasis and affecting the growth and differentiation of certain neoplastic cells, 1 alpha, 25-(OH)2D3 can also suppress the formation of chemically induced tumors.Entities:
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Year: 1983 PMID： 6689123 DOI： 10.1016/0006-291x(83)90567-3
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575