Literature DB >> 6689106

Inhibition of phospholipase A2 and platelet aggregation by glycyrrhizin, an antiinflammation drug.

E Okimasu, Y Moromizato, S Watanabe, J Sasaki, N Shiraishi, Y M Morimoto, M Miyahara, K Utsumi.   

Abstract

We studied the effect of glycyrrhizin, a compound known as an anti-inflammatory and antiallergic drug, on the membrane permeability change induced by phospholipase A2 (PLA2) and on platelet aggregation. Glycyrrhizin was found to inhibit the PLA2-induced carboxyfluorescein (CF) release from D,L-dipalmitoyl phosphatidylcholine (DPPC) liposomes. Part of this inhibitory effect of glycyrrhizin on PLA2 is accounted for by the physical state of the substrate, the DPPC liposome membrane. Glycyrrhizin also inhibited collagen-induced platelet aggregation in a concentration dependent manner, which may in part account for its inhibitory effect on PLA2.

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Year:  1983        PMID： 6689106     DOI： 10.18926/AMO/32426

Source DB:  PubMed          Journal:  Acta Med Okayama        ISSN： 0386-300X            Impact factor:   0.892


  12 in total

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5.  Application of an amine functionalized biopolymer in the colonic delivery of glycyrrhizin: a design and in vivo efficacy study.

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Journal:  Sci Pharm       Date:  2013-05-18

Review 6.  Insight into Oral Biofilm: Primary, Secondary and Residual Caries and Phyto-Challenged Solutions.

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7.  Quantitative analysis of Glycyrrhizic acid from a polyherbal preparation using liquid chromatographic technique.

Authors:  Amit K De; Sriparna Datta; Arup Mukherjee
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8.  Application of spray granulation for conversion of mixed phospholipid-bile salt micelles to dry powder form: influence of drug hydrophobicity on nanoparticle reagglomeration.

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Journal:  Int J Nanomedicine       Date:  2014-01-15

9.  Comparing The Effects of Glycyrrhiza glabra Root Extract, A Cyclooxygenase-2 Inhibitor (Celecoxib) and A Gonadotropin-Releasing Hormone Analog (Diphereline) in A Rat Model of Endometriosis.

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10.  Glycyrrhizin prevents of lipopolysaccharide/D-galactosamine-induced liver injury through down-regulation of matrix metalloproteinase-9 in mice.

Authors:  Kazuki Abe; Tadayuki Ikeda; Kenjiro Wake; Tetsuji Sato; Toshitsugu Sato; Hideo Inoue
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