| Literature DB >> 6688884 |
E G de Toranzo, M Masana, J A Castro.
Abstract
Rat and human feces are able to reduce nitro group from Benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) and Nifurtimox (4[5-nitrofurfurylidene)-amino)-3-methylthiomorpholine-1,1-dioxide), two chemotherapeutic agents against Chagas' disease. Feces from rats treated with neomycin sulfate lack nitroreductase activity evidencing the bacterial origin of the enzyme.Entities:
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Year: 1983 PMID： 6688884
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164