Prediction of multiple-dose blood level curves of drugs with rapid changes in doses and/or dosing intervals.

This paper describes a program which can predict multiple-dose blood level curves of any drug administered orally or intravenously with up to a maximum of three changes in the dosage regimen at any time during the treatment period. This program is applicable to any drug in a given individual provided that the single-dose blood level curve equation (in the form of a two-exponential function) of the first or the last dose of the therapy in this individual is known.