Literature DB >> 6688226

The effect of N-methylprotoporphyrin and succinyl-acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture.

F De Matteis, G S Marks.   

Abstract

The essential features of hepatic protoporphyria, namely inhibition of ferrochelatase, accumulation of protoporphyrin and stimulation of 5-aminolevulinic acid synthase (ALA-S) were all obtained by treating chicken hepatocytes in culture with small doses of N-methylprotoporphyrin. Both N-methylprotoporphyrin and succinyl-acetone, another inhibitor of heme biosynthesis, stimulated ALA-S when given on their own and also enhanced the stimulation of ALA-S caused by phenobarbital.

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Year:  1983        PMID： 6688226     DOI： 10.1016/0014-5793(83)80430-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Heme bioavailability and signaling in response to stress in yeast cells.

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Review 2.  Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.

Authors:  Maria Almira Correia; Peter R Sinclair; Francesco De Matteis
Journal:  Drug Metab Rev       Date:  2010-09-23       Impact factor: 4.518

3.  ApoHRP-based assay to measure intracellular regulatory heme.

Authors:  Hani Atamna; Marmik Brahmbhatt; Wafa Atamna; Gregory A Shanower; Joseph M Dhahbi
Journal:  Metallomics       Date:  2015-02       Impact factor: 4.526

4.  Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma.

Authors:  Kishore Polireddy; Hemantkumar Chavan; Bashar A Abdulkarim; Partha Krishnamurthy
Journal:  Mol Oncol       Date:  2011-07-28       Impact factor: 6.603

5.  The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells.

Authors:  K Mitani; H Fujita; Y Fukuda; A Kappas; S Sassa
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

6.  Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer in vitro.

Authors:  Yalei Zhao; Xiaoyun Zhang; Yabin Liu; Yiping Ma; Pong Kong; Tianliang Bai; Mei Han; Binghui Li
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7.  Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.

Authors:  Sarada Preeta Kalainayakan; Poorva Ghosh; Sanchareeka Dey; Keely E Fitzgerald; Sagar Sohoni; Purna Chaitanya Konduri; Massoud Garrossian; Li Liu; Li Zhang
Journal:  Sci Rep       Date:  2019-02-05       Impact factor: 4.379

8.  Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target.

Authors:  Shiming Zhang; Glenn S Gerhard
Journal:  PLoS One       Date:  2009-10-28       Impact factor: 3.240

9.  Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells.

Authors:  Jagmohan Hooda; Daniela Cadinu; Md Maksudul Alam; Ajit Shah; Thai M Cao; Laura A Sullivan; Rolf Brekken; Li Zhang
Journal:  PLoS One       Date:  2013-05-21       Impact factor: 3.240

10.  Erythrophagocytosis enhances heme-dependent cytotoxicity of antimalarial drugs in canine histiocytic sarcoma cell line DH82.

Authors:  Seishiro Chikazawa; Yasunori Kitahara; Erika Ando; Yasutomo Hori; Fumio Hoshi; Kazutaka Kanai; Naoyuki Ito; Seiichi Higuchi
Journal:  J Vet Med Sci       Date:  2013-09-20       Impact factor: 1.267
  10 in total

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