Literature DB >> 668805

Antibody diversity in amphibians: inheritance of isoelectric focusing antibody patterns in isogenic frogs.

L Du Pasquier, M R Wabl.   

Abstract

Anti-sheep red cell, anti-dinitrophenyl, anti-phosphorylcholine antibody responses have been followed in isogenic frogs of the genus Xenopus. Isoelectric focusing antibody patterns show a high degree of overlap for all antigens studied, and a heterogeneity that is lower than in mammals for the same antigens. Inheritance of antibody isoelectric focusing spectrotypes was demonstrated for sheep red cells and dinitrophenyl in two clones of isogenic animals. Outbred frogs show a higher frequency of spectrotype sharing than outbred mammals. It is therefore suggested that antibody diversity is lower in frogs than in mammals.

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Year:  1978        PMID： 668805     DOI： 10.1002/eji.1830080611

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  14 in total

1.  Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis.

Authors:  R N Haire; C T Amemiya; D Suzuki; G W Litman
Journal:  J Exp Med       Date:  1990-05-01       Impact factor: 14.307

Review 2.  Developmental aspects of B-cell repertoire phenotype.

Authors:  M P Cancro; M A Thompson; D M Hilbert
Journal:  Surv Immunol Res       Date:  1983

3.  Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.

Authors:  E Hsu; J Schwager; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

4.  The effect of adult thymectomy upon helper function in Xenopus laevis, the South African clawed toad.

Authors:  D A Gruenewald; L N Ruben
Journal:  Immunology       Date:  1979-09       Impact factor: 7.397

5.  The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of families.

Authors:  R N Haire; Y Ohta; R T Litman; C T Amemiya; G W Litman
Journal:  Nucleic Acids Res       Date:  1991-06-11       Impact factor: 16.971

6.  Immunoglobulin VH gene structure and diversity in Heterodontus, a phylogenetically primitive shark.

Authors:  G W Litman; L Berger; K Murphy; R Litman; K Hinds; B W Erickson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

7.  The expression of antibody diversity in natural and laboratory-made polyploid individuals of the clawed toad Xenopus.

Authors:  L Du Pasquier; B Blomberg
Journal:  Immunogenetics       Date:  1982-03       Impact factor: 2.846

Review 8.  Comparative and developmental study of the immune system in Xenopus.

Authors:  Jacques Robert; Yuko Ohta
Journal:  Dev Dyn       Date:  2009-06       Impact factor: 3.780

9.  What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

Authors:  M Wilson; E Hsu; A Marcuz; M Courtet; L Du Pasquier; C Steinberg
Journal:  EMBO J       Date:  1992-12       Impact factor: 11.598

10.  The ontogeny of diversification at the immunoglobulin heavy chain locus in Xenopus.

Authors:  J Schwager; N Bürckert; M Courtet; L Du Pasquier
Journal:  EMBO J       Date:  1991-09       Impact factor: 11.598
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