Literature DB >> 668788

m-Trifluoromethyl-alpha-ethylbenzhydrol: a new enzyme inducer.

B Gachályi, A Káldor, S Szeberényi.   

Abstract

The enzyme inducing effect of m-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332) has been studied in man, rat and mouse. In man, RGH-3332 decreased the half-life of antipyrine and tolbutamide and increased D-glucaric acid excretion. In rat and mouse the half-life of antipyrine was shortened. It was concluded that in all three species man, rat and mouse the liver microsomal drug metabolizing enzyme system was induced by RGH-3332. No side-effects were found on treatment with RGH-3332.

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Year:  1978        PMID： 668788     DOI： 10.1007/BF00716366

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  18 in total

1.  [The possibility of colorimetric determination of N-(4-methyl-benzolsulfonyl)-N'-butyl urea in blood].

Authors:  H SPINGLER
Journal:  Klin Wochenschr       Date:  1957-05-15

2.  The estimation of antipyrine in biological materials.

Authors:  B B BRODIE; J AXELROD
Journal:  J Biol Chem       Date:  1949-05       Impact factor: 5.157

3.  Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.

Authors:  W Zilly; D D Breimer; E Richter
Journal:  Eur J Clin Pharmacol       Date:  1977-04-20       Impact factor: 2.953

4.  Individual differences in the plasma half-lives of lipid soluble drugs in man.

Authors:  D S Davies; S S Thorgeirsson
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1971

5.  The metabolism of tolbutamide in rat liver.

Authors:  H G McDaniel; H Podgainy; R Bressler
Journal:  J Pharmacol Exp Ther       Date:  1969-05       Impact factor: 4.030

6.  Glucaric acid as an indicator of use of enzyme-inducing drugs.

Authors:  E A Sotaniemi; F Medzihradsky; G Eliasson
Journal:  Clin Pharmacol Ther       Date:  1974-04       Impact factor: 6.875

7.  Hepatic microsomal enzyme induction and its evaluation in a clinical laboratory.

Authors:  M Herzberg; B Fishel; M H Wiener
Journal:  Isr J Med Sci       Date:  1977-05

8.  Phenobarbital effects in cholestatic liver diseases.

Authors:  J R Bloomer; J L Boyer
Journal:  Ann Intern Med       Date:  1975-03       Impact factor: 25.391

9.  Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer on the central nervous system of rats. Part II.

Authors:  E Pálosi; S Szeberényi; L Szporny
Journal:  Arzneimittelforschung       Date:  1978

10.  Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer, on the microsomal drug metabolism. Part I.

Authors:  S Szeberényi; E Pálosi; L Szporny
Journal:  Arzneimittelforschung       Date:  1978
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  2 in total

1.  Pharmacokinetic studies of flumecinol in man and dog.

Authors:  I Klebovich; L Vereczkey; S Kerpel-Fronius; G Ringwald; I Bodrogligeti
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1982       Impact factor: 2.441

2.  The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man.

Authors:  J T Lahtela; B Gachalyi; S Eksymä; A Hämäläinen; E A Sotaniemi
Journal:  Br J Clin Pharmacol       Date:  1986-01       Impact factor: 4.335
  2 in total

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