Literature DB >> 6687416

Biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3.

S Okamoto, Y Tanaka, H F DeLuca, Y Kobayashi, N Ikekawa.   

Abstract

The biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 was compared with 1,25-dihydroxyvitamin D3 in the rat. The 24,24-difluoro-1,25-dihydroxyvitamin D3 has a potency of approximately 5-10 times that of 1,25-dihydroxyvitamin D3 in the known in vivo vitamin D responsive systems. These systems include intestinal calcium transport, bone calcium mobilization, calcification of epiphyseal plate cartilage, and elevation of plasma calcium and phosphorus concentrations. Thus, 24,24-difluoro-1,25-dihydroxyvitamin D3 is the first known analogue with higher potency than 1,25-dihydroxyvitamin D3 in vivo.

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Year:  1983        PMID： 6687416     DOI： 10.1152/ajpendo.1983.244.2.E159

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  3 in total

1.  Elongation of the side chain of analogs of 1 alpha,25-dihydroxyvitamin D3 prevents osteopenia in a rat model.

Authors:  M Harada; T Takamura; S Kajita-Kondo; A Kozakai; T Miyahara; H Kozuka; N Ikekawa; S Higuchi; S Otomo
Journal:  Calcif Tissue Int       Date:  1995-03       Impact factor: 4.333

2.  Calcium regulating activity of 26,27-dialkyl analogs of 1 alpha,25-dihydroxyvitamin D3.

Authors:  T Miyahara; M Harada; M Miyata; A Sugure; Y Ikemoto; T Takamura; S Higuchi; S Otomo; H Kozuka; N Ikekawa
Journal:  Calcif Tissue Int       Date:  1992-09       Impact factor: 4.333

3.  Calcium regulating activity of 24a-homo-24,24-difluoro-1 alpha,25-dihydroxyvitamin D3 and 26,27-dimethyl-24,24-difluoro-1 alpha,25-dihydroxyvitamin D3.

Authors:  M Harada; T Miyahara; M Miyata; H Komiyama; A Sugure; Y Ikemoto; S Kondo; T Takamura; S Higuchi; S Otomo
Journal:  Calcif Tissue Int       Date:  1993-11       Impact factor: 4.333
  3 in total

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