Effects of jejunal reinfusion of aspirated duodenal fluid on biliary and pancreatic secretion in man.

The standard duodenal perfusion technique was used to measure biliary and pancreatic secretion in normal subjects, with and without jejunal reinfusion of aspirated duodenal fluid. In studies carried out without reinfusion of the duodenal aspirate, and where a continuous background stimulation of caerulein and secretin was given throughout the studies to eliminate extrahepatic biliary storage, a gradual fall in bile salt and bilirubin secretion was observed. In contrast, when the experiments were carried out in these same individuals, and under exactly the same experimental conditions except that the duodenal aspirate, rich in bile and pancreatic juice, was in every successive collection period reinfused into the jejunum, the bile salt secretion remained stable and the bilirubin secretion increased. In neither series of studies were there any definite changes in the secretory output of trypsin. The total secretory output of bicarbonate was, however, marginally greater in studies carried out with jejunal reinfusion of the aspirate than in the studies where the aspirate was discarded. Carried out under basal conditions, a gradual fall in both biliary and pancreatic secretion was observed in both series of studies. These results indicate that partial diversion of bile and pancreatic juice from the jejunum in man may affect hepato-biliary secretion of bile salts and bilirubin and the secretion of bicarbonate.

RCT Entities:   Population Interventions Outcomes