Literature DB >> 6686675

Further studies on the role of noradrenergic mechanisms in ethanol withdrawal syndrome in rats.

E Trzaskowska, W Kostowski.   

Abstract

Ethanol dependence was induced in rats by intragastric administration of ethanol. Clonidine (0.1 mg/kg ip) suppressed withdrawal reaction while yohimbine (2.5 mg/kg ip) produced an opposite effect. Propranolol (2.0 mg/kg ip) reduced withdrawal convulsions but not locomotor hyperactivity while prazosin (1.0 mg/kg ip) attenuated only the latter symptom. Electrolytic lesions in the ventral noradrenergic bundle slightly increased locomotor activity in ethanol-dependent rats but failed to change the convulsions. Our result indicates that drugs acting upon alpha and beta adrenoceptors are able to reduce the severity of certain withdrawal reactions in ethanol-dependent rats.

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Year:  1983        PMID： 6686675

Source DB:  PubMed          Journal:  Pol J Pharmacol Pharm        ISSN： 0301-0244


  9 in total

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8.  Label-Free Proteomic Analysis of Protein Changes in the Striatum during Chronic Ethanol Use and Early Withdrawal.

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9.  The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice.

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  9 in total

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