Literature DB >> 6685501

Synthesis of orally active cardiosteroid derivatives.

J Engel, O Isaac, K Posselt, K Thiemer, H Uthemann.   

Abstract

Starting from hellebrigenin, orally cardiotonic active acylcardiosteroid derivatives have been synthesized. D 12316 (acrihellin), the hellebrigenin-3 beta-dimethylacrylate, has been chosen for clinical evaluation.

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Year:  1983        PMID： 6685501

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  2 in total

1.  Acrihellin, a cardioactive steroid escaping from the organ-bath.

Authors:  S Herzig; H Lüllmann; K Mohr; B Seemann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-03       Impact factor: 3.000

2.  The lead structure in cardiac glycosides is 5 beta, 14 beta-androstane-3 beta 14-diol.

Authors:  W Schönfeld; J Weiland; C Lindig; M Masnyk; M M Kabat; A Kurek; J Wicha; K R Repke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-06       Impact factor: 3.000
  2 in total

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