Literature DB >> 6685336

Mechanisms of renal excretion of cisdichlorodiamine platinum.

R Caterson, S Etheredge, P Snitch, G Duggin.   

Abstract

Eighteen diuretic rabbits were given cisdichlorodiamine platinum (CDDP) and the clearance of plasma water platinum was determined with a simultaneous inulin clearance. The rabbits were then given probenecid (50 mg/kg) or choline (50 mg/kg) and the clearance of free platinum was calculated. CDDP has a high clearance, exceeding glomerular filtration rate. The drug appears to be secreted by the anionic transport system in the proximal tubule, as the clearance of free platinum is markedly decreased by the administration of probenecid.

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Year:  1983        PMID： 6685336

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  7 in total

Review 1.  Saturable pharmacokinetics in the renal excretion of drugs.

Authors:  C A van Ginneken; F G Russel
Journal:  Clin Pharmacokinet       Date:  1989-01       Impact factor: 6.447

2.  Evaluation of the effect of furosemide on ultrafilterable platinum kinetics in patients treated with cis-diamminedichloroplatinum.

Authors:  M Dumas; C de Gislain; P d'Athis; V Chadoint-Noudeau; A Escousse; J Guerrin; N Autissier
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

3.  Nonlinear renal clearance of ultrafilterable platinum in patients treated with cis-dichlorodiammineplatinum (II).

Authors:  P A Reece; I Stafford; J Russell; P G Gill
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

4.  Pharmacokinetics and plasma protein binding of two platinum cytostatics CHIP and CBDCA in rats.

Authors:  A Láznícková; M Láznícek; J Kvĕtina; J Drobník
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

5.  Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.

Authors:  K K Filipski; R H Mathijssen; T S Mikkelsen; A H Schinkel; A Sparreboom
Journal:  Clin Pharmacol Ther       Date:  2009-07-22       Impact factor: 6.875

6.  Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.

Authors:  S Hu; A F Leblanc; A A Gibson; K W Hong; J Y Kim; L J Janke; L Li; A Vasilyeva; D B Finkelstein; J A Sprowl; D H Sweet; E Schlatter; G Ciarimboli; Jhm Schellens; S D Baker; N Pabla; A Sparreboom
Journal:  Clin Transl Sci       Date:  2017-07-08       Impact factor: 4.689

7.  Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions.

Authors:  Jason T Anderson; Kevin M Huang; Maryam B Lustberg; Alex Sparreboom; Shuiying Hu
Journal:  Rev Physiol Biochem Pharmacol       Date:  2022       Impact factor: 7.500
  7 in total

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