Literature DB >> 6685239

Pick's disease (lobar sclerosis): depletion of neurons in the nucleus basalis of Meynert.

G R Uhl, D C Hilt, J C Hedreen, P J Whitehouse, D L Price.   

Abstract

The nucleus basalis of Meynert (nbM) has been implicated in the pathogenesis of the presynaptic cholinergic deficiency in the cerebrum of patients with Alzheimer's disease. To further define the role of this cholinergic basal forebrain nucleus in dementia, we examined the nbM in two patients with lobar sclerosis, or Pick's disease (PD). The brains of both of these patients showed substantial reductions in the number of nerve cells in many neuronal populations, including the nbM. Our observations of the changes in the nbM are correlated with previous investigations of cholinergic markers in PD.

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Year:  1983        PMID： 6685239     DOI： 10.1212/wnl.33.11.1470

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

Review 1.  Recent advances in the understanding of dementia.

Authors:  P Tyrrell; M Rossor
Journal:  Postgrad Med J       Date:  1988-02       Impact factor: 2.401

2.  MR analysis of the substantia innominata in normal aging, Alzheimer disease, and other types of dementia.

Authors:  Haruo Hanyu; Tetsuichi Asano; Hirofumi Sakurai; Yuriko Tanaka; Masaru Takasaki; Kimihiko Abe
Journal:  AJNR Am J Neuroradiol       Date:  2002-01       Impact factor: 3.825

3.  Neuropathological study on the nucleus basalis of Meynert in Pick's disease.

Authors:  K Mizukami; K Kosaka
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

Review 4.  Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies.

Authors:  Gregory A Jicha
Journal:  J Mol Neurosci       Date:  2011-06-07       Impact factor: 3.444

5.  Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options.

Authors:  Gregory A Jicha; Peter T Nelson
Journal:  Neurodegener Dis Manag       Date:  2011-04

6.  Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease.

Authors:  P R Hof; C Bouras; D P Perl; J H Morrison
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

Review 7.  A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia.

Authors:  Edward D Huey; Karen T Putnam; Jordan Grafman
Journal:  Neurology       Date:  2006-01-10       Impact factor: 9.910

8.  The nucleus basalis of Meynert in multi-infarct (vascular) dementia.

Authors:  D M Mann; P O Yates; B Marcyniuk
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

9.  Neocortical morphometry and cholinergic neurochemistry in Pick's disease.

Authors:  L A Hansen; R Deteresa; H Tobias; M Alford; R D Terry
Journal:  Am J Pathol       Date:  1988-06       Impact factor: 4.307

Review 10.  Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance.

Authors:  Changiz Geula; Sara R Dunlop; Ivan Ayala; Allegra S Kawles; Margaret E Flanagan; Tamar Gefen; Marek-Marsel Mesulam
Journal:  J Neurochem       Date:  2021-08-06       Impact factor: 5.546
  10 in total

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