Literature DB >> 6684692

Absence of genetic heterogeneity in Duchenne muscular dystrophy shown by a linkage study using two cloned DNA sequences.

T O'Brien, P S Harper, K E Davies, J M Murray, M Sarfarazi, R Williamson.   

Abstract

A linkage study using two different restriction fragment length polymorphisms (RFLPs) identified with cloned DNA sequences has failed to provide evidence for genetic heterogeneity in Duchenne muscular dystrophy (DMD) when tested against intelligence quotient (IQ). Analysis of data for age of confinement to a wheelchair against IQ gave no evidence for heterogeneity. These results are of a practical as well as theoretical significance, since the existence of multiple loci causing DMD would make it more difficult to apply linkage data to genotype prediction in this disease.

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Year:  1983        PMID： 6684692      PMCID： PMC1049113          DOI： 10.1136/jmg.20.4.249

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  8 in total

1.  Intellectual function in childhood progressive muscular dystrophy.

Authors:  D K WORDEN; P J VIGNOS
Journal:  Pediatrics       Date:  1962-06       Impact factor: 7.124

2.  Linkage between the loci for benign (Becker-type) X-borne muscular dystrophy and deutan colour blindness.

Authors:  R Skinner; C Smith; A E Emery
Journal:  J Med Genet       Date:  1974-12       Impact factor: 6.318

3.  The genetic relationship of progressive muscular dystrophy (Duchenne type) and mental retardation.

Authors:  H J Cohen; G E Molnar; L T Taft
Journal:  Dev Med Child Neurol       Date:  1968-12       Impact factor: 5.449

4.  The use of linked DNA polymorphisms for genotype prediction in families with Duchenne muscular dystrophy.

Authors:  P S Harper; T O'Brien; J M Murray; K E Davies; P Pearson; R Williamson
Journal:  J Med Genet       Date:  1983-08       Impact factor: 6.318

5.  Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

Authors:  J M Murray; K E Davies; P S Harper; L Meredith; C R Mueller; R Williamson
Journal:  Nature       Date:  1982-11-04       Impact factor: 49.962

Review 6.  Clinical features and classification of the muscular dystrophies.

Authors:  D Gardner-Medwin
Journal:  Br Med Bull       Date:  1980-05       Impact factor: 4.291

7.  A study of possible heterogeneity in Duchenne muscular dystrophy.

Authors:  A E Emery; R Skinner; S Holloway
Journal:  Clin Genet       Date:  1979-05       Impact factor: 4.438

8.  Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome.

Authors:  K E Davies; P L Pearson; P S Harper; J M Murray; T O'Brien; M Sarfarazi; R Williamson
Journal:  Nucleic Acids Res       Date:  1983-04-25       Impact factor: 16.971
  8 in total
  6 in total

1.  Interpretation of RFLP linkage data.

Authors:  J F Clayton
Journal:  J Med Genet       Date:  1984-04       Impact factor: 6.318

Review 2.  Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.

Authors:  H Moser
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

3.  Implications of diagnostic delay in Duchenne muscular dystrophy.

Authors:  T O'Brien; J R Sibert; P S Harper
Journal:  Br Med J (Clin Res Ed)       Date:  1983-10-15

4.  Genetic heterogeneity in Duchenne muscular dystrophy.

Authors:  A E Emery
Journal:  J Med Genet       Date:  1984-02       Impact factor: 6.318

5.  Mapping DNA sequences in a human X-chromosome deletion which extends across the region of the Duchenne muscular dystrophy mutation.

Authors:  C Ingle; R Williamson; A de la Chapelle; R R Herva; K Haapala; G Bates; H F Willard; P Pearson; K E Davies
Journal:  Am J Hum Genet       Date:  1985-05       Impact factor: 11.025

6.  Duchenne muscular dystrophy. Frequency of sporadic cases.

Authors:  G A Danieli; G Barbujani
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132
  6 in total

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