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Literature DB >> 6684463

Bioavailability of methyl-14C CDP-choline by oral route.

Abstract

In this work, the bioavailability of the 14C-methyl-labelled cytidine diphosphate choline (CDP-Choline, citicoline, Somazina), has been studied by oral route, leading to the result that it is slowly and completely absorbed, with a very low urinary and fecal elimination, thus producing maintained blood levels. The bioavailability related to oral route compared with intravenous route is practically the same.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1983 PMID： 6684463

Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172

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Cited

11 in total

1. CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.

Authors: Rao Muralikrishna Adibhatla; J F Hatcher; K Tureyen
Journal: Brain Res Date: 2005-10-05 Impact factor: 3.252

2. Functional rescue in a mouse model of congenital muscular dystrophy with megaconial myopathy.

Authors: Ambreen A Sayed-Zahid; Roger B Sher; Stacey J Sukoff Rizzo; Laura C Anderson; Kathryn E Patenaude; Gregory A Cox
Journal: Hum Mol Genet Date: 2019-08-15 Impact factor: 6.150

3. Enhanced therapeutic effect of cytidine-5'-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model.

Authors: M Fresta; E Wehrli; G Puglisi
Journal: Pharm Res Date: 1995-11 Impact factor: 4.200

4. Effect of oral CDP-choline on visual function in young amblyopic patients.

Authors: Michela Fresina; Anna Dickmann; Annabella Salerni; Fabio De Gregorio; Emilio C Campos
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2007-07-19 Impact factor: 3.117

5. Label-free CEST MRI Detection of Citicoline-Liposome Drug Delivery in Ischemic Stroke.

Authors: Huanling Liu; Anna Jablonska; Yuguo Li; Suyi Cao; Dexiang Liu; Hanwei Chen; Peter Cm Van Zijl; Jeff W M Bulte; Miroslaw Janowski; Piotr Walczak; Guanshu Liu
Journal: Theranostics Date: 2016-06-18 Impact factor: 11.556

Review 6. Cytidine 5'-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use, Current Evidence and Future Perspectives.

Authors: Gloria Roberti; Lucia Tanga; Manuele Michelessi; Luciano Quaranta; Vincenzo Parisi; Gianluca Manni; Francesco Oddone
Journal: Int J Mol Sci Date: 2015-11-30 Impact factor: 5.923

Bioavailability of methyl-14C CDP-choline by oral route.

1. CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.

2. Functional rescue in a mouse model of congenital muscular dystrophy with megaconial myopathy.

3. Enhanced therapeutic effect of cytidine-5'-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model.

4. Effect of oral CDP-choline on visual function in young amblyopic patients.

5. Label-free CEST MRI Detection of Citicoline-Liposome Drug Delivery in Ischemic Stroke.

Review 6. Cytidine 5'-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use, Current Evidence and Future Perspectives.

Review 7. Neuroprotective agents in the management of glaucoma.

Review 8. Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function.

Review 9. Cytidine 5'-Diphosphocholine (Citicoline): Evidence for a Neuroprotective Role in Glaucoma.

Review 10. Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review.